Active Recombinant Human SIGLEC6 Homodimer Protein, His tagged

• Cat.No.: SIGLEC6-56H
• Product Overview: Siglec-6 protein dimer contains a Siglec-6 extracellular domain (UniProt# O43699) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: His
• Protein Length: 27-347 aa
• Description: Human sialic acid-binding Ig-like lectin 6 (Siglec-6) is a Type I transmembrane protein, a member of the Siglec family, part of the immunoglobulin superfamily, and a multifunctional immune regulator. Siglec-6 is also known as Cluster of Differentiation 327 (CD327), CD33-like (CD33L), CD33L1, CD33L2, and CDW327. Siglec-6 contains an extracellular domain with an N-terminal V-type immunoglobulin domain (Ig domain) and two C2-type Ig domains followed by a transmembrane domain and cytoplasmic signaling domain consisting of the immunoreceptor tyrosine-based inhibitory motif (ITIM). Siglec-6 is expressed on trophoblasts and highly expressed on mast cells from a variety of tissues. It binds sialylated glycans on cell surfaces or secreted proteins, modulating cell-cell interactions and immune responses. The presence of Siglec-6 on various kinds of leukemias has made it an emerging target for cancer therapeutics.
• Molecular Mass: 87 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for Siglec-6-specific antibody binding assays. Suggested Applications: SPR & BLI for Siglec-6-specific antibody binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: SIGLEC6 sialic acid binding Ig-like lectin 6 [ Homo sapiens (human) ]
• Official Symbol: SIGLEC6
• Synonyms: SIGLEC6; sialic acid binding Ig-like lectin 6; CD33L, CD33L1; sialic acid-binding Ig-like lectin 6; CD327; OB BP1; SIGLEC 6; CD33 antigen-like 1; obesity-binding protein 1; CD33L; OBBP1; CD33L1; CD33L2; CDW327
• Gene ID: 946
• mRNA Refseq: NM_001177547
• Protein Refseq: NP_001171018
• MIM: 604405
• UniProt ID: O43699