Active Recombinant Human TMEM106B Protein, Fc tagged

• Cat.No.: TMEM106B-12H
• Product Overview: Recombinant Human TMEM106B Protein (Pro118-Gln274) with Human IgG1 (Pro100-Lys330) Fc tag at N-terminus was expressed in Human embryonic kidney cell. N-terminal Sequence Analysis: Met

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 118-274 aa
• Description: Enables ATPase binding activity. Involved in dendrite morphogenesis and lysosome localization. Located in endosome and lysosomal membrane. Implicated in hypomyelinating leukodystrophy 16.
• Form: Disulfide linked homodimer. Supplied as a 0.2 μm filtered solution in PBS with Trehalose.
• Bio-activity: Measured by its binding ability in a functional ELISA. Recombinant Human TMEM106B Fc Chimera binds Recombinant SARS-CoV-2 Spike RBD His-tag (HEK293 Expressed) with ED50 < 2.00 μg/mL.
• Molecular Mass: 45 kDa
• Endotoxin: < 0.10 EU/μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
• Applications: Bioactivity
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after opening. 3 months, -20 to -70 centigrade under sterile conditions after opening.
• Shipping: The product is shipped with dry ice or equivalent.

Gene Information

• Gene Name: TMEM106B transmembrane protein 106B [ Homo sapiens (human) ]
• Official Symbol: TMEM106B
• Synonyms: TMEM106B; transmembrane protein 106B; HLD16; transmembrane protein 106B
• Gene ID: 54664
• mRNA Refseq: NM_001134232
• Protein Refseq: NP_001127704
• MIM: 613413
• UniProt ID: Q9NUM4