Active Recombinant Mouse Cxcl1 Protein (Asn29-Lys96), Animal-free, Carrier-free

• Cat.No.: Cxcl1-33M
• Product Overview: Recombinant Mouse Cxcl1 Protein (Asn29-Lys96) without tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: C-X-C motif chemokine 1 (CXCL1) also named Growth-regulated oncogene alpha (GROα), which is a chemokine of the intercrine alpha family. CXCL1 is a 7.5 kDa protein containing 68 amino acid residues. CXCL1 is often expressed in immune cells such as macrophage and neutrophils. CXCL1 plays an important role with immune responses and cancer progression. CXCL1 activates the cell signal transduction with casepas1 that affects the cell proliferation, differentiation and migration.
• Source: E. coli
• Species: Mouse
• Tag: Non
• Form: Lyophilized
• Bio-activity: Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2. The ED50 for this effect is < 15 ng/mL.
• Molecular Mass: The protein has a calculated MW of 7.45 kDa.
  The protein migrates below 11 kDa under reducing condition (SDS-PAGE analysis).
• Protein Length: Asn29-Lys96
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >95% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution containing 50 mM Tris and 150 mM NaCl, pH 8.5.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 110 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: Cxcl1 chemokine (C-X-C motif) ligand 1 [ Mus musculus (house mouse) ]
• Official Symbol: Cxcl1
• Synonyms: CXCL1; chemokine (C-X-C motif) ligand 1; growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1
• Gene ID: 14825
• mRNA Refseq: NM_008176
• Protein Refseq: NP_032202
• UniProt ID: P12850

Reviews

06/15/2020

Efficient delivery, great service.

01/01/2019

Product as described, perfect.

10/13/2018

Reliable for protein work.

Q&As

Are there any therapeutic strategies targeting CXCL1?

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation?

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression?

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis?

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system?

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated?

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells?

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.