Active Recombinant Mouse Il17a Protein
Cat.No. : | Il17a-094M |
Product Overview : | Purified recombinant protein of Mouse interleukin 17A (Il17a) (Ala26-Ala158) without tag was expressed in E.coli. |
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Description : | This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
Source : | E. coli |
Species : | Mouse |
Bio-activity : | The ED50 is 0.25 - 1 ng/ml, corresponding to a specific activity 1.0 - 4 x 10^6 units/mg, determined by a dose dependent stimulation of fetal mouse skin fibroblasts production of IL-6. |
Molecular Mass : | 15 kDa |
Endotoxin : | Less than 0.01 ng per µg protein as determined by the LAL method |
Purity : | >98%, as determined by Coomassie stained SDS-PAGE. |
Stability : | Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | Protein formulated and vialed at >50 ug/mL in specified buffer |
Storage Buffer : | 10 mM NaH2PO4, 0.15 M NaCl, pH7.2 |
Protein length : | Ala26-Ala158 |
Gene Name : | Il17a interleukin 17A [ Mus musculus (house mouse) ] |
Official Symbol : | Il17a |
Synonyms : | Il17a; interleukin 17A; Il17; Ctla8; IL-17; Ctla-8; IL-17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8 |
Gene ID : | 16171 |
mRNA Refseq : | NM_010552 |
Protein Refseq : | NP_034682 |
UniProt ID : | Q62386 |
Products Types
◆ Recombinant Protein | ||
IL17A-137H | Active Recombinant Human IL17A Protein | +Inquiry |
IL17A-48H | Recombinant Human IL17A Protein | +Inquiry |
IL17A-1166H | Recombinant Human IL17A Protein, His (Fc)-Avi-tagged | +Inquiry |
IL17A-848M | Recombinant Mouse IL17A Protein (Ala26-Ala158) | +Inquiry |
IL17A-1812H | Recombinant Human IL17A protein(26-132aa), His-GST-tagged | +Inquiry |
◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
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