Active Recombinant Mouse Il1b Protein (153 aa)
| Cat.No. : | Il1b-365I |
| Product Overview : | Recombinant mouse Interleukin-1 Beta(rmIL-1β) produced in E. coli is a single non-glycosylated polypeptide chain containing 153 amino acids. A fully biologically active molecule, rmIL-1β is obtained by proprietary chromatographic techniques, with an apparent molecular weight of 17.5kDa analyzed by reducing SDS-PAGE. |
- Specification
- Gene Information
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| Description : | Interleukin-1 Beta (IL-1β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. |
| Source : | E. coli |
| Species : | Mouse |
| Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : | ED50< 2.0 pg/mL, measured by the dose-dependent stimulation of mouse D10S cells, corresponding to a specific activity of> 5.0 × 10^8units/mg. |
| Molecular Mass : | 17.5kDa, observed by reducing SDS-PAGE. |
| Protein Length : | 153 |
| AA Sequence : | MVPIRQLHYRLRDEQQKSLVLSDPY ELKALHLNGQNINQQVIFSMSFVQG EPSNDKIPVALGLKGKNLYLSCVMK DGTPTLQLESVDPKQYPKKKMEKRF VFNKIEVKSKVEFESAEFPNWYIST SQAEHKPVFLGNNSGQDIIDFTMES VSS |
| Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
| Purity : | > 95% by SDS-PAGE and HPLC analyses. |
| Storage : | Lyophilized recombinant mouseInterleukin-1 Beta(rmIL-1β) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rmIL-1β should be stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade. |
| Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
| Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
| Gene Name : | Il1b interleukin 1 beta [ Mus musculus ] |
| Official Symbol : | Il1b |
| Synonyms : | IL1B; interleukin 1 beta; interleukin-1 beta; IL-1 beta; Il-1b; IL-1beta; |
| Gene ID : | 16176 |
| mRNA Refseq : | NM_008361 |
| Protein Refseq : | NP_032387 |
| UniProt ID : | P10749 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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