Active Recombinant Mouse Il6 Protein, His-tagged

• Cat.No.: Il6-237I
• Product Overview: Recombinant Mouse Il6 Protein with a His tag was expressed in CHO.

Specification

• Description: Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that participates in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, and nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction and released into the blood stream to help break down fats and improve insulin resistance.
• Source: CHO
• Species: Mouse
• Tag: His
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: ED50 < 3 pg/mL, measured in a bioassay using 7TD1 cells.
• Molecular Mass: 24-26 kDa, observed by reducing SDS-PAGE.
• AA Sequence: FPTSQVRRGDFTEDTTPNRPVYTTS QVGGLITHVLWEIVEMRKELCNGNS DCMNNDDALAENNLKLPEIQRNDGC YQTGYNQEICLLKISSGLLEYHSYL EYMKNNLKDNKKDKARVLQRDTETL IHIFNQEVKDLHKIVLPTPISNALL TDKLESQKEWLRTKTIQFILKSLEE FLKVTLRSTRQTHHHHHH
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 95% as analyzed by SDS-PAGE.
• Storage: Lyophilized recombinant murine Interleukin-6 (IL-6), His, Murine remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, murine Interleukin-6 (IL-6), His should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: Il6 interleukin 6 [ Mus musculus ]
• Official Symbol: Il6
• Synonyms: IL6; interleukin 6; interleukin-6; interleukin HP-1; B-cell hybridoma growth factor; Il-6
• Gene ID: 16193
• mRNA Refseq: NM_031168
• Protein Refseq: NP_112445
• UniProt ID: P08505

Reviews

03/05/2022

Accurate localization and function within the cell.

01/31/2021

The binding affinity and affinity constant with the target are high.

03/12/2020

Can form a stable micellar structure.

Q&As

What is the dosage and usage of Il6?

The dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.

What are the pharmacokinetic properties of Il6?

The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.

Does Il6 have advantages in the treatment of multiple myeloma?

Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.

Does Il6 have specific therapeutic effects for certain diseases?

Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.

In which diseases is Il6 widely used?

This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.

What is the effect of Il6 on immune cells?

The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.