Active Recombinant Rhesus Macaque IL18
Cat.No. : | IL18-370R |
Product Overview : | Recombinant Rhesus Macaque IL18 (Accession # AAK13416) Tyr37-Asp193 was produced in E. coli-derived. |
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Source : | E. coli |
Species : | Rhesus Macaque |
Predicted N Terminal : | Tyr37 |
Form : | Lyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4, EDTA and DTT with BSA as a carrier protein. |
Bio-activity : | Measured by its ability to induce IFN-gamma secretion by KG-1 human acute myelogenous leukemia cells in the presence of TNF-alpha.The ED50 for this effect is typically 1-4 ng/mL in the presence of 20 ng/mL recombinant human TNF-alpha. |
Molecular Mass : | Recombinant Rhesus Macaque IL18 has a calculated MW of 18.2 kDa. |
Purity : | >97%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Reconstitution : | Reconstitute at 10 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Tag : | Non |
Gene Name : | IL18 interleukin 18 (interferon-gamma-inducing factor) [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | IL18 |
Synonyms : | IL18; interleukin 18 (interferon-gamma-inducing factor); interleukin-18; interleukin-18 proprotein |
Gene ID : | 574151 |
mRNA Refseq : | NM_001032834 |
Protein Refseq : | NP_001028006 |
MIM : | |
Chromosome Location : | 14 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewEffective in inflammation models.
High stability in serum.
Suitable for ELISA.
Q&As (10)
Ask a questionCo-immunoprecipitation, co-localization studies, and pathway inhibition assays decipher IL18's interactions with signaling molecules and pathways.
Therapeutic antibody trials, in vitro drug screens, and disease model assessments assess IL18-targeted interventions in autoimmune diseases.
Xenograft models, intravital imaging, and tissue-specific knockout approaches unravel IL18's kinetics and effects within complex in vivo environments.
Flow cytometry, chemotaxis assays, and functional cell assays examine IL18's impact on immune cell activation, migration, and effector functions.
Surface plasmon resonance, mutational studies, and phosphoproteomics illuminate IL18's receptor interactions and downstream signal transduction pathways.
Immunophenotyping, cytokine profiling, and gene expression analyses elucidate IL18's influence on Th cell polarization and immune balance.
ChIP assays, promoter analyses, and epigenetic profiling uncover the regulatory mechanisms underlying IL18 gene expression dynamics.
Disease models, knockout mice, and co-stimulation studies explore IL18's involvement in inflammatory conditions and its interplay with other proinflammatory mediators.
Tumor models, immune profiling, and immunotherapeutic studies investigate IL18's modulation of the tumor microenvironment and its implications for cancer therapy.
Caspase assays, cytokine ELISAs, and microscopy techniques unveil the activation of inflammasomes and IL18's contribution to pyroptosis and cytokine storms.
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