Recombinant Human Aminoacylase 1, His-tagged

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Recombinant Human Aminoacylase 1, His-tagged

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Cat. No. : ACY1-781H
Product Overview : Recombinant human ACY1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =48.0kDa (428aa) confirmed by MALDI-TOF.
Description : Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MTSKGPEEEH PSVTLFRQYL RIRTVQPKPD YGAAVAFFEE TARQLGLGCQ KVEVAPGYVV TVLTWPGTNP TLSSILLNSH TDVVPVFKEH WSHDPFEAFK DSEGYIYARG AQDMKCVSIQ YLEAVRRLKV EGHRFPRTIH MTFVPDEEVG GHQGMELFVQ RPEFHALRAG FALDEGIANP TDAFTVFYSE RSPWWVRVTS TGRPGHASRF MEDTAAEKLH KVVNSILAFR EKEWQRLQSN PHLKEGSVTS VNLTKLEGGV AYNVIPATMS ASFDFRVAPD VDFKAFEEQL QSWCQAAGEG VTLEFAQKWM HPQVTPTDDS NPWWAAFSRV CKDMNLTLEP EIMPAATDNR YIRAVGVPAL GFSPMNRTPV LLHDHDERLH EAVFLRGVDI YTRLLPALAS VPALPSDS
Purity : > 90% by SDS – PAGE.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 1mM DTT.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 1q7l. :

Gene Name : ACY1 aminoacylase 1 [ Homo sapiens ]
Synonyms : ACY1; aminoacylase 1; ACY1D; ACYLASE; aminoacylase-1; N-acyl-L-amino-acid amidohydrolase; ACY-1; EC 3.5.1.14
Gene ID : 95
mRNA Refseq : NM_000666
Protein Refseq : NP_000657
MIM : 104620
UniProt ID : Q03154
Chromosome Location : 3p21.1
Pathway : Arginine and proline metabolism; Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid; Metabolic pathways
Function : aminoacylase activity; hydrolase activity; metal ion binding; metal ion binding; metallopeptidase activity; protein dimerization activity; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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