Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 2), His-tagged LTA-5068H

Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 2), His-tagged

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Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 2), His-tagged

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Cat. No. : LTA-5068H
roduct Overview : Recombinant LTAprotein was expressed in E. coli and purified by using conventionalchromatography techniques.
Description : LTA, a member of thetumor necrosis factor family, is a cytokine produced by lymphocytes. Theprotein is highly inducible, secreted, and forms heterotrimers withlymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. Thisprotein also mediates a large variety of inflammatory, immunostimulatory, andantiviral responses, is involved in the formation of secondary lymphoidorgans during development and plays a role in apoptosis.
Concentration : 0.5 mg/ml
Source : Human
Host : E. coli
Form : Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 30% glycerol, 0.1MNaCl, and 1mM DTT.
Purity : > 90% by SDS -PAGE
Sequence : 35-205 amino acids:MGSSHHHHHH SSGLVPRGSH MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANTDRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQKMVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL
Molecular Mass : 20.9 kDa(192aa), confirmed by MALDI-TOF.
Applications : SDS-PAGE
Storage : Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : LTA
PDBrendering based on 1tnr. :

Gene Name : LTAlymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ]
Synonyms : LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB;TNFSF1; lymphotoxin-alpha; LT-alpha; TNF-beta; OTTHUMP00000029184;OTTHUMP00000165897; tumor necrosis factor beta; tumor necrosis factor ligandsuperfamily member 1
Gene ID : 4049
mRNA Refseq : NM_000595
Protein Refseq : NP_000586
MIM : 153440
UniProt ID : P01374
Chromosome Location : 6p21.3
Pathway : Apoptosis;Cytokine-cytokine receptor interaction; HTLV-I infection; Herpes simplexinfection; IL2 signaling events mediated by STAT5; IL4-mediated signaling events;Type I diabetes mellitus
Function : cytokineactivity; receptor binding; tumor necrosis factor receptor binding

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