Recombinant Human Chemokine (C-C motif) Ligand 21

• Cat.No.: CCL21-341H
• Product Overview: Recombinant human CCL21is a single, non-glycosylated polypeptide chain containing 111 amino acids.CCL21 is expressed in E. coli, MW 12.2 kDa.

Specification

• Cat. No.: CCL21-341H
• Description: Chemokine (C-Cmotif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokinefamily. This chemokine is also known as 6Ckine (because it has six conservedcysteine residues instead of the four cysteines typical to chemokines),exodus-2, and secondary lymphoid-tissue chemokine (SLC). The gene for CCL21is located on human chromosome 9. CCL21 elicits its effects by binding to acell surface chemokine receptor known as CCR7.
• Source: Human
• Host: E. coli
• Form: Lyophilizedfrom a sterile filtered solution in 20 mM PB, pH 7.4 + 150 mM NaCl.
• Purity: > 97% asdetermined by HPLC and SDS-PAGE analyses.
• Sequence: SDGGAQDCCLKYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGCRKDRGASKTG KKGKGSKGCR KTERSQTPKG P
• Molecular Weight: 12.2 kDa
• Biological Activity: Calculatedby the ability to chemoattract lymphocytes using a concentration of10.0-100.0ng/ml.
• Endotoxin Level: < 0.1ng/µg Exodus 2
• Reconstitution: Centrifugevial prior to opening. Add sterile distilled water or aqueous buffer containing0.1% BSA to a concentration of 0.1-1.0 mg/mL. Please note that the additionof any carrier protein into this product may produce unwanted endotoxin. Thisdepends upon the particular application employed. Further dilutions should bemade in appropriate buffered solutions.
• Storage: Stableat 2-8°C, but best kept desiccated -20°C. Upon reconstitution, stable for upto 1 week at 2-8°C. For longer term, store in working aliquots below -20°C. Avoidrepeated freeze/thaw cycles.
• OfficialSymbol: CCL21

Gene Information

• Gene Name: CCL21chemokine (C-C motif) ligand 21 [ Homo sapiens ]
• Synonyms: CCL21; chemokine (C-C motif) ligand 21; ECL; SLC; CKb9; TCA4;6Ckine; SCYA21; MGC34555; C-C motif chemokine 21; exodus-2;OTTHUMP00000021303; OTTHUMP00000021304; beta chemokine exodus-2;beta-chemokine exodus-2; small-inducible cytokine A21; secondary lymphoidtissue chemokine; secondary lymphoid-tissue chemokine; EfficientChemoattractant for Lymphocytes; small inducible cytokine subfamily A(Cys-Cys), member 21
• Gene ID: 6366
• mRNA Refseq: NM_002989
• Protein Refseq: NP_002980
• MIM: 602737
• UniProt ID: O00585
• Chromosome Location: 9p13
• Pathway: Chemokinereceptors bind chemokines; Chemokine signaling pathway; Class A/1(Rhodopsin-like receptors); Cytokine-cytokine receptor interaction; G alpha(i) signalling events; GPCR downstream signaling; GPCR ligand binding;Peptide ligand-binding receptors; Signaling by GPCR
• Function: CCR7chemokine receptor binding; chemokine activity

Reviews

11/21/2022

CCL21 products are reliable and stable, and are widely used in scientific research, industrial production and medical fields.

04/10/2022

CCL21 has a long half-life and can maintain stability and reliability during the experiment.

06/28/2021

When using CCL21 protein for experiments, it can meet specific experimental requirements and research purposes.

Q&As

Does CCL21 have relationships with other genes or proteins?

This has a complex relationship with other genes or proteins, and can interact with other genes or proteins to participate in a variety of biochemical reactions.

What are the applications of CCL21 in medical treatment?

It can be used as a biomarker in medical treatment to help monitor disease progression and treatment efficacy. In addition, therapeutics targeting CCL21, such as targeted therapies or modulating its expression, are also being investigated.

What diseases can CCL21 deficiency or aberrant expression cause?

CCL21 deficiency or aberrant expression may be associated with some autoimmune diseases, cancer, and neurodegenerative diseases.

Might abnormal CCL21 levels be indicative of disease?

Abnormal levels of CCL21 may suggest autoimmune diseases, cancer, and neurodegenerative diseases, but they may also be associated with other diseases.

How to study the regulatory mechanism of CCL21?

Studying the regulatory mechanism of CCL21 requires a combination of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

How are mutations in CCL21 detected and analyzed?

Mutations in CCL21 can be detected and analyzed by methods such as whole-genome sequencing or target region sequencing to understand the impact of mutations on protein structure and function.