"PTPN1" Related Products

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Recombinant Human Protein Tyrosine Phosphatase, Non-Receptor Type 1, GST-tagged

Cat. No.: PTPN1-1908H
Product Overview: RecombinantHuman PTPN1, full length, (aa 1-436) with N-terminal GST tag.
Description: PTPN1 (PTP1B) isan enzyme that is the founding member of the protein tyrosine phosphatase(PTP) family. In humans it is encoded by the PTPN1 gene. PTPN1 is anegative regulator of the insulin signaling pathway and is considered apromising potential therapeutic target, in particular for treatment of type 2diabetes.
Source: E. coli
Species: Human
Form: Liquid in 25 mM Tris-HCl, pH 8.0 +100 mM NaCl + 0.05% Tween-20 + 50% glycerol + 3 mM DTT.
Molecular Weight: 76kDa
Purity: > 70%
Specific Activity: 10 U/ug.One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.Assay buffer: 50 mM HEPES, pH 7.4 + 2 mM EDTA + 3mM DTT + 100 mM NaCl + 50mM Pnpp.
Applications: Useful for the study of enzymekinetics, regulation, to dephosphorylate target substrates and forscreening inhibitors.
Storage: Stablefor 6 months at -80°C. Avoid repeated freeze-thaw cycles.
Pathways: Adherensjunction; Calcineurin-regulated NFAT-dependent transcription in lymphocytes;Cytokine Signaling in Immune system; EGF receptor (ErbB1) signaling pathway;Growth hormone receptor signaling; Hemostasis; IGF1 pathway; Immune System;Insulin Pathway; Insulin signaling pathway; Integrin alphaIIb beta3signaling; Interferon alpha/beta signaling; N-cadherin signaling events;PDGFR-beta signaling pathway; Regulation of IFNA signaling
Gene Name: PTPN1protein tyrosine phosphatase, non-receptor type 1 [ Homo sapiens ]
Official Symbol: PTPN1
Synonyms: PTPN1;protein tyrosine phosphatase, non-receptor type 1; PTP1B; tyrosine-proteinphosphatase non-receptor type 1; OTTHUMP00000031266; protein tyrosinephosphatase 1B; protein-tyrosine phosphatase 1B; protein tyrosine phosphatase,placental
Gene ID: 5770
mRNA Refseq: NM_002827
Protein Refseq: NP_002818
MIM: 176885
UniProt ID: P18031
Chromosome Location: 20q13.1-q13.2
Function: ephrinreceptor binding; hydrolase activity; insulin receptor binding; proteinbinding; protein tyrosine phosphatase activity; zinc ion binding

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