Native Human Von Willebrand Factor

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Native Human Von Willebrand Factor

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Cat. No. : VWF-369H
Product Overview : Native human VWF isprepared from citrated human plasma using a combination of chromotographicprocedures.
Description : Von Willebrandfactor is prepared from citrated human plasma using a combination ofchromotographic procedures. The preparations consist of large multimers asdetermined by electrophoresis in SDS/agarose gels. Molecular weight is 250000(monomer), 1-20 X 1000000 (multimers).
Source : Human plasma
Species : Human
Form : Frozen liquid in abuffer of 0.025M Sodium Citrate + 0.1M NaCl + 0.1M glycine, pH 6.8.
Purity : >95% pure bySDS-PAGE under reducing conditions.
MolecularWeight : 260 kDa (Monomer)
Concentration : 0.2 mg/ml
Certification : Although thestarting material was tested prior to initiation of the manufacturing processand was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s),HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme cautionshould be used when handling this material as there is a margin of error inall tests.
Storage : Store at -80°C. Thawin a 37°C water bath for 2-3 minutes without agitation.
OfficialSymbol : VWF
Pathways : Blood ClottingCascade; Complement and Coagulation Cascades; ECM-receptor interaction; FocalAdhesion; Formation of Fibrin Clot (Clotting Cascade); GP1b-IX-V activationsignalling; Hemostasis; Integrin alphaIIb beta3 signaling; Integrin cellsurface interactions; Intrinsic Pathway; Platelet Adhesion to exposedcollagen; Platelet Aggregation (Plug Formation); Platelet activation;Platelet degranulation
PDB rendering basedon 1ao3. :

Gene Name : VWF von Willebrand factor [ Homosapiens ]
Synonyms : VWF; vonWillebrand factor; VWD; F8VWF; coagulation factor VIII VWF; von Willebrand antigen II
Gene ID : 7450
mRNA Refseq : NM_000552
Protein Refseq : NP_000543
MIM : 613160
UniProt ID : P04275
Chromosome Location : 12p13.3
Function : chaperone binding;collagen binding; glycoprotein binding; immunoglobulin binding; integrinbinding; protease binding; protein N-terminus binding; protein binding;protein homodimerization activity

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