Native Human Coagulation Factor XIII, A1 Polypeptide

• Cat.No.: F13A1-5399H
• Product Overview: Native Human F13A1 was expressed in Human plasma and molecular weight is 312 kDa.

Specification

• Description: Human F13A1is producted from Factor XIII by cleavage with human alpha thrombin. FactorXIII is a tetramer composed of two pairs of chains held together by noncovalentbonds. Thrombin cleaves activation peptides from the alpha chains of FactorXIII (MW = 320 kDa) generating activated Factor XIIIa (MW = 312 kDa). The thrombinis subsequently removed via chromatography.
• Source: Human plasma
• Species: Human
• Form: Frozenliquid containing 0.05 M Tris-HCl Buffer + 0.15 M NaCl + 0.001 M EDTA + 10 U/mlAprotinin + 20% Glycerol, pH 7.5.
• Molecular Mass: 312 kDa
• Endotoxin: < 0.1 ng/μg ofprotein.>
• Purity: ≥95% by SDS-PAGEanalysis.
• Storage: Store at -20°C.Stable for 12 months from delivery. Avoid repeated freeze-thaw cycles.
• Concentration: 5.0 mg/ml

Gene Information

• Gene Name: F13A1 coagulation factor XIII, A1 polypeptide [ Homo sapiens ]
• Official Symbol: F13A1
• Synonyms: F13A1; coagulation factor XIII, A1 polypeptide; F13A; coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit
• Gene ID: 2162
• mRNA Refseq: NM_000129
• Protein Refseq: NP_000120
• MIM: 134570
• UniProt ID: P00488
• Chromosome Location: 6p24.2-p23
• Pathway: Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem
• Function: metal ion binding; protein-glutamine gamma-glutamyltransferase activity; protein-glutamine gamma-glutamyltransferase activity; transferase activity, transferring acyl groups