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Native Bovine Coagulation Factor II (thrombin)

Cat.No. : F2-5401B
Product Overview : Native Bovine F2 was expressed in Bovine Plasma.
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Description : Bovine F2 is a multifunctional proteolytic enzyme which acts both specifically andnon-specifically with several proteins, cells, surfaces, and other molecules.Bovine F2 plays an essential role in the clotting process where it convertsfibrinogen, a soluble plasma glycoprotein, to an insoluble protein gel calledfibrin, the essential component of the blood clot.
Source : Bovine Plasma
Species : Bovine
Form : Lyophilized
Molecular Mass : 36kDa
Storage : Store at -20°C.
Gene Name : F2 coagulation factor II (thrombin) [ Homo sapiens ]
Official Symbol : F2
Synonyms : F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1;
Gene ID : 2147
mRNA Refseq : NM_000506
Protein Refseq : NP_000497
MIM : 176930
UniProt ID : P00734
Chromosome Location : 11p11-q12
Pathway : Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem;
Function : calcium ion binding; growth factor activity; peptidase activity; protein binding; receptor binding; contributes_to receptor binding; serine-type endopeptidase activity; thrombospondin receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of the F2 gene in the synthesis of vitamin K-dependent clotting factors, and how disruptions in this process may lead to coagulation disorders? 04/10/2022

The F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.

How is the F2 gene regulated at the transcriptional level, and what factors influence prothrombin synthesis in hepatocytes? 08/07/2021

Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation. 04/07/2020

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.

What are the implications of genetic variations in the F2 gene, particularly polymorphisms, on prothrombin function and susceptibility to thrombotic or bleeding disorders? 11/20/2019

Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.

How does genetic variation in the F2 gene impact prothrombin levels, and what are the consequences for an individual's risk of thrombotic events? 04/16/2018

Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.

Customer Reviews (3)

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Reviews
01/01/2022

    Quality control is evident. This product ensures accuracy in our studies.

    01/27/2019

      Our lab swears by this protein. Fast shipping is a definite bonus.

      12/18/2018

        Consistently reliable. The shipping speed is appreciated in our fast-paced lab.

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