Native Bovine Coagulation Factor II (thrombin)
Cat.No. : | F2-5401B |
Product Overview : | Native Bovine F2 was expressed in Bovine Plasma. |
- Specification
- Gene Information
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Description : | Bovine F2 is a multifunctional proteolytic enzyme which acts both specifically andnon-specifically with several proteins, cells, surfaces, and other molecules.Bovine F2 plays an essential role in the clotting process where it convertsfibrinogen, a soluble plasma glycoprotein, to an insoluble protein gel calledfibrin, the essential component of the blood clot. |
Source : | Bovine Plasma |
Species : | Bovine |
Form : | Lyophilized |
Molecular Mass : | 36kDa |
Storage : | Store at -20°C. |
Gene Name : | F2 coagulation factor II (thrombin) [ Homo sapiens ] |
Official Symbol : | F2 |
Synonyms : | F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1; |
Gene ID : | 2147 |
mRNA Refseq : | NM_000506 |
Protein Refseq : | NP_000497 |
MIM : | 176930 |
UniProt ID : | P00734 |
Chromosome Location : | 11p11-q12 |
Pathway : | Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; |
Function : | calcium ion binding; growth factor activity; peptidase activity; protein binding; receptor binding; contributes_to receptor binding; serine-type endopeptidase activity; thrombospondin receptor activity; |
Products Types
◆ Recombinant Protein | ||
F2-1356R | Recombinant Rhesus Macaque F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-789H | Recombinant Human F2 Protein | +Inquiry |
F2-955H | Recombinant Human F2 Protein, MYC/DDK-tagged | +Inquiry |
F2-995M | Recombinant Mouse F2 Protein, MYC/DDK-tagged | +Inquiry |
F2-069H | Recombinant Human F2 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Native Protein | ||
F2-1882H | Native Human Coagulation Factor II | +Inquiry |
F2-5286R | Native Rat Coagulation Factor II | +Inquiry |
Thrombin-61M | Active Native Mouse Thrombin | +Inquiry |
◆ Lysates | ||
F2-2124MCL | Recombinant Mouse F2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.
Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.
The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.
Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.
Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.
Customer Reviews (3)
Write a reviewQuality control is evident. This product ensures accuracy in our studies.
Our lab swears by this protein. Fast shipping is a definite bonus.
Consistently reliable. The shipping speed is appreciated in our fast-paced lab.
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