"GSK3B" Related Products

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Recombinant Human Glycogen Synthase Kinase 3 Beta, GST-tagged

Cat. No.: GSK3B-1886H
Product Overview: Recombinant humanfull length GSK3B with N-terminal GST tag.
Description: GSTK3Bis a serine threonine protein kinase that was originally identified as thekinase the phosphorylates and inhibits glycogen synthase. GSK3B isubiquitously present in human tissues and implicated in the regulation ofseveral physiological processes, including the control of glycogen andprotein synthesis by insulin, and modulation of the transcription factorsAP-1 and CREB. Transient transfection of human GSK3B into CHO cells stablytransfected with individual human tau isoforms leads to hyperphosphorylationof tau at all the sites investigated with phosphorylation-dependent anti-tauantibodies.
Source: Insect cells
Species: Human
Form: Liquid in 50 mMTris-HCl, pH 7.5 + 150 mM NaCl + 0.25 mM DTT + 0.1 mM EGTA + 0.1 mM EDTA +0.1 PMSF + 25% glycerol.
Molecular Weight: 73 kDa
Purity: > 90% asdetermined by densitometry
Specific Activity: 187 nmol/min/mg
Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: GSK3B
Gene Name: GSK3B glycogen synthase kinase 3beta [ Homo sapiens ]
Synonyms: GSK3B; glycogen synthase kinase3 beta; glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform;OTTHUMP00000165239; OTTHUMP00000165240
Gene ID: 2932
mRNA Refseq: NM_002093
Protein Refseq: NP_002084
MIM: 605004
UniProt ID: P49841
Chromosome Location: 3q13
Pathway: AKT phosphorylates targets inthe cytosol; Aurora A signaling; Axon guidance; Axon guidance; B CellReceptor Signaling Pathway; B cell receptor signaling pathway; BMP receptorsignaling; Basal cell carcinoma; C-MYC pathway; CRMPs in Sema3A signaling;Cell cycle; Colorectal cancer; Delta-Notch Signaling Pathway; Endometrialcancer; Energy Metabolism
Function: NF-kappaB binding; NF-kappaBbinding; RNA polymerase II transcription factor binding; beta-cateninbinding; kinase activity; nucleotide binding; p53 binding; protein binding;protein kinase A catalytic subunit binding; protein kinase binding; proteinserine/threonine kinase activity; tau-protein kinase activity; ubiquitinprotein ligase binding

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