"MAP4K5" Related Products


Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5, GST-tagged

Cat. No. : MAP4K5-375H
Product Overview : Recombinant human full length MAP4K5,GST-tagged is expressed in Insect cells.
Description : MAP4K5is an enzyme that in humans is encoded by the MAP4K5 gene. This gene encodesa member of the serine/threonine protein kinase family that is highly similarto yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning ofthe MAP kinase signal cascades that is essential for yeast pheromoneresponse. This kinase was shown to activate Jun kinase in mammalian cells,which suggested a role in stress response. Two alternatively splicedtranscript variants encoding the same protein have been described for thisgene.
Source : Insect cells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
Molecular Weight : 122.5 kDa
Concentration : 0.5 mg/ml
Specific Activity : 780 nmole of phosphate transferred tomyelin basic protein (MBP) per minute per mg of total protein at 30°C.Activity determined at a final protein concentration of 0.83 μg/ml.
Storage : Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : MAP4K5
nullValue_other :
FunctionATPbinding; nucleotide binding; protein serine/tyreonine kinase activity; protein binding;small GTPase regulator activity; protein kinase activity
Gene Name : MAP4K5mitogen-activated protein kinase kinase kinase kinase 5 [ Homo sapiens ]
Synonyms : MAP4K5;mitogen-activated protein kinase kinase kinase kinase 5; KHS; KHS1; GCKR; germinalcenter kinase-relate; EC; Kinase homologous to SPS1/STE20; MAPK/ERKkinase kinase kinase 5; MEK kinase kinase 5; MEKKK5; MEKKKK5; EC 2.7.11;OTTHUMP00000244662
Gene ID : 11183
mRNA Refseq : NM_006575
Protein Refseq : NP_006566
MIM : 604923
UniProt ID : Q9Y4K4
Chromosome Location : 14q11.2-q21
Pathway : Insulin Signaling;TNF receptor signalingpathway

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