Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5, GST-tagged

• Cat.No.: MAP4K5-375H
• Product Overview: Recombinant human full length MAP4K5,GST-tagged is expressed in Insect cells.

Specification

• Cat. No.: MAP4K5-375H
• Description: MAP4K5is an enzyme that in humans is encoded by the MAP4K5 gene. This gene encodesa member of the serine/threonine protein kinase family that is highly similarto yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning ofthe MAP kinase signal cascades that is essential for yeast pheromoneresponse. This kinase was shown to activate Jun kinase in mammalian cells,which suggested a role in stress response. Two alternatively splicedtranscript variants encoding the same protein have been described for thisgene.
• Source: Insect cells
• Species: Human
• Form: Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
• Molecular Weight: 122.5 kDa
• Concentration: 0.5 mg/ml
• Specific Activity: 780 nmole of phosphate transferred tomyelin basic protein (MBP) per minute per mg of total protein at 30°C.Activity determined at a final protein concentration of 0.83 μg/ml.
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: MAP4K5
• Function: ATPbinding; nucleotide binding; protein serine/tyreonine kinase activity; protein binding;small GTPase regulator activity; protein kinase activity

Gene Information

• Gene Name: MAP4K5mitogen-activated protein kinase kinase kinase kinase 5 [ Homo sapiens ]
• Synonyms: MAP4K5;mitogen-activated protein kinase kinase kinase kinase 5; KHS; KHS1; GCKR; germinalcenter kinase-relate; EC 2.7.11.1; Kinase homologous to SPS1/STE20; MAPK/ERKkinase kinase kinase 5; MEK kinase kinase 5; MEKKK5; MEKKKK5; EC 2.7.11;OTTHUMP00000244662
• Gene ID: 11183
• mRNA Refseq: NM_006575
• Protein Refseq: NP_006566
• MIM: 604923
• UniProt ID: Q9Y4K4
• Chromosome Location: 14q11.2-q21
• Pathway: Insulin Signaling;TNF receptor signalingpathway