Recombinant Human Janus Kinase 3, GST-tagged

• Cat.No.: JAK3-1887H
• Product Overview: Recombinant humanJAK3 catalytic domain (amino acids 781-1124), GST-tagged. No special measureswere taken to activate this kinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 781-1124 a.a.
• Description: JAK3 is a member of the JAKfamily of tyrosine kinases involved in cytokine receptor-mediatedintracellular signal transduction. Low levels of JAK3 expression is detectedin immature hematopoietic cells, which dramatically increases during terminaldifferentiation of these cells suggesting a role of JAK3 in thedifferentiation of hematopoietic cells. Mutations in JAK3 are associated withautosomal SCID (severe combined immunodeficiency disease. Mice lacking JAK3show a severe block in B-cell development at the pre-B stage in bone marrowsuggesting that JAK3 is critical for the progression of B-cell development inthe bone marrow.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT + 50%glycerol.
• Molecular Weight: 67.4 kDa
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: JAK3

Gene Information

• Gene Name: JAK3 Janus kinase 3 [ Homosapiens ]
• Synonyms: JAK3; Janus kinase 3; JAKL;LJAK; JAK-3; L-JAK; JAK3_HUMAN; leukocyte Janus kinase; tyrosine-proteinkinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); EC2.7.10.2
• Gene ID: 3718
• mRNA Refseq: NM_000215
• Protein Refseq: NP_000206
• MIM: 600173
• UniProt ID: P52333
• Chromosome Location: 19p13.1
• Pathway: Chemokine signaling pathway;Jak-STAT signaling pathway; Primary immunodeficiency; HTLV-Iinfection; IL-2 Signaling Pathway; IL-4 signaling Pathway; IL-7 SignalingPathway; IL-9 Signaling Pathway; IL2 signaling events mediated by PI3K; IL4-mediatedsignaling events; Immune System; Interleukin receptor SHC signaling
• Function: ATP binding; Janus kinaseactivity; non-membrane spanning protein tyrosine kinase activity; nucleotidebinding; protein binding; transferase activity