| Cat. No. : |
CAB-T9002H |
| Product Overview : |
Mab to IL12B. Recombinant monoclonal antibody to Human IL 12B. |
| Antigen Description : |
Cytokine that can act as a growth factorfor activated T and NK cells, enhance the lytic activity ofNK/lymphokine-activated Killer cells, and stimulate the production ofIFN-gamma by resting PBMC. |
| Protein Costruction : |
DNA sequences codingH and L chains of Anti-human interleukin-12/23 monoclonal antibody cotransfected to host cell were expressed. |
| Isotype : |
IgG |
| Formulation : |
Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements. |
| Purity Detail : |
>95% asdetermined by SDS-PAGE and HPLC |
| Source : |
Culture Supernatant |
| Expression Host : |
Chinese HamsterOvary (CHO cell) |
| Endotoxin : |
<1.0EUper 10 mg protein as determined by the LAL method |
| Molecular Mass : |
The secretedrecombinant Anti-human interleukin-12/23 monoclonal antibody comprises 1326amino acids. As a result of glycosylation, it has molecular mass of 150kDa inSDS-PAGE under non-reducing conditions. |
| Predicted N terminal : |
H chain: EVQLVQSGAE;Lchain:DIQMTQSPSS |
| Stability : |
Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C. |
| Storage : |
Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage. |
| Background : |
The recombinant antibody targets the epitope of IL12. Like Briakinumab or ustekinumab,whichis directed against interleukin 12 naturally occurring proteins that regulatethe immune system and immune-mediated inflammatory disorders. Anti-humaninterleukin-12/23 monoclonal antibody is a human IgG1 monoclonal antibodythat binds to subunit of p40, which is used by IL-12 and IL-23. It isproduced in Chinese hamster ovary (CHO) cells. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.