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| Cat. No.: | CAB-T9002H |
| Product Overview: | Mab to IL12B. Recombinant monoclonal antibody to Human IL 12B. |
| Antigen Description: | Cytokine that can act as a growth factorfor activated T and NK cells, enhance the lytic activity ofNK/lymphokine-activated Killer cells, and stimulate the production ofIFN-gamma by resting PBMC. |
| Protein Costruction: | DNA sequences codingH and L chains of Anti-human interleukin-12/23 monoclonal antibody cotransfected to host cell were expressed. |
| Isotype: | IgG |
| Formulation: | Normally 1mg/mlL-His, 1mg/ml Sucrose and 0.04 mg/ml Tween-80 are added, pH 6.0. Pleasecontact us for any concerns or special requirements. |
| Purity Detail: | >95% asdetermined by SDS-PAGE and HPLC |
| Source: | Culture Supernatant |
| Expression Host: | Chinese HamsterOvary (CHO cell) |
| Endotoxin: | <1.0EUper 10 mg protein as determined by the LAL method |
| Molecular Mass: | The secretedrecombinant Anti-human interleukin-12/23 monoclonal antibody comprises 1326amino acids. As a result of glycosylation, it has molecular mass of 150kDa inSDS-PAGE under non-reducing conditions. |
| Predicted N terminal: | H chain: EVQLVQSGAE;Lchain:DIQMTQSPSS |
| Stability: | Samples are stablefor up to twelve months from date of receipt at -20°C and are stable forsix months at 4°C. |
| Storage: | Store it understerile conditions at -70°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage. |
| Background: | The recombinant antibody targets the epitope of IL12. Like Briakinumab or ustekinumab,whichis directed against interleukin 12 naturally occurring proteins that regulatethe immune system and immune-mediated inflammatory disorders. Anti-humaninterleukin-12/23 monoclonal antibody is a human IgG1 monoclonal antibodythat binds to subunit of p40, which is used by IL-12 and IL-23. It isproduced in Chinese hamster ovary (CHO) cells. |
| Gene Name: | IL12B interleukin 12B(natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturationfactor 2, p40) [ Homo sapiens ] |
| Official Symbol: | IL12B |
| Synonyms: | IL12B; CLMF; NKSF; CLMF2; NKSF2; IL-12B;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxiclymphocyte maturation factor 2, p40); interleukin-12 subunit beta CLMF p40; IL-12 subunit p40; IL12, subunit p40; OTTHUMP00000160820;interleukin 12, p40; interleukin-12 beta chain; NK cell stimulatory factorchain 2; cytotoxic lymphocyte maturation factor 40 kDa subunit; naturalkiller cell stimulatory factor, 40 kD subunit |
| Gene ID: | 3593 |
| mRNA Refseq: | NM_002187 |
| Protein Refseq: | NP_002178 |
| MIM: | 161561 |
| UniProt ID: | P29460 |
| Chromosome Location: | 5q31.1-q33.1 |
| Pathway: | African trypanosomiasis, organism-specific biosystem; Africantrypanosomiasis, conserved biosystem; Allograft rejection, organism-specificbiosystem; Allograft rejection, conserved biosystem; Amoebiasis,organism-specific biosystem; Amoebiasis, conserved biosystem; Chagas disease(American trypanosomiasis), organism-specific biosystem; Chagas disease (Americantrypanosomiasis), conserved biosystem; Cytokine-cytokine receptorinteraction, organism-specific biosystem; Cytokine-cytokine receptorinteraction, conserved biosystem; Cytokines and Inflammatory Response,organism-specific biosystem; |
| Function: | contributes_tocytokine activity; cytokine receptor activity; contributes_to growth factoractivity; identical protein binding; interleukin-12 alpha subunit binding; interleukin-12receptor binding; contributes_to interleukin-12 receptor binding; contributes_tointerleukin-23 receptor binding; protein binding; protein heterodimerizationactivity; protein homodimerization activity; signal transducer activity |
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