"ADAM8" Related Products


Recombinant Human ADAM Metallopeptidase Domain 8, His-tagged

Cat. No. : ADAM8-525H
Product Overview : Recombinant Human ADAM8protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Met1-Pro497.
Description : ADAM8, also known ascell surface antigen MS2 or CD156a, is a member of the ADAM family that containsa disintegrin and metalloproteaselike domain. ADAM8 can cleave a variety of substratesand has been shown as a sheddase for the low affinity IgE receptor CD23 andthe neural recognition molecule CHL1. Expression and regulation studiessuggest that ADAM8 is a novel osteoclast stimulating factor and may play arole in asthma.
Source : Murine myeloma cellline, NS0-derived.
Form : Supplied as a 0.2 μmfiltered solution in Glycerol, Tris, NaCl and CaCl2.
N-terminalSequence : Glu158
Molecular Weight : 38 kDa
Activity : Measuredby its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-DpaRSSSR-NH2,The specific activity is > 1 pmol/min/μg, as measured under the described conditions.
Endotoxin Level : < 1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE : 42 kDa, reducingconditions.
Purity : > 90%, by SDSPAGEunder reducing conditions and visualized by silver stain.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt,-20 to -70°C as supplied. 3 months, -20 to -70°C under sterile conditionsafter opening.
Gene Name : ADAM8 ADAM metallopeptidasedomain 8 [ Homo sapiens ]
Official Symbol : ADAM8
Synonyms : ADAM8; ADAMmetallopeptidase domain 8; MS2; CD156; CD156a; disintegrin andmetalloproteinase domain-containing protein 8; cell surface antigen MS2;human leukocyte differentiation antigen; a disintegrin and metalloproteinasedomain 8; EC 3.4.24.-
Gene ID : 101
mRNA Refseq : NM_001109
Protein Refseq : NP_001100
MIM : 602267
UniProt ID : P78325
Chromosome Location : 10q26.3
Function : calcium ion binding;cell adhesion molecule binding; metalloendopeptidase activity;metallopeptidase activity; peptidase activity; protein binding; protein self-association;zinc ion binding

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