"FZD8" Related Products


Recombinant Human Frizzled Family Receptor 8, Fc-tagged

Cat. No. : FZD8-597H
Product Overview : RecombinantHuman FZD8 protein was expressed in Chinese Hamster Ovary cell line with theFc part of Human IgG1 Pro100-Lys330 (C-terminus) and Human Frizzled-8 Ala25-Pro172(N-terminus).
Description : FZD8 is one of atleast ten seventransmembrane (7TM) glycoprotein of the Frizzled family of Wntreceptors. Frizzled proteins are thought to be G-protein-coupled. Wnt engagement,with low density lipoprotein receptor related proteins LRP-5 or LRP-6 actingas co-receptors stabilizes β-catenin and promotes gene transcription that isimportant in development and tissue maintenance.
Source : Chinese HamsterOvary cell line, CHO-derived
Form : Supplied as a 0.2 μmfiltered solution in PBS.
N-terminal Sequence : Ala25 & Ala28
Molecular Weight : 43.3 kDa
Activity : Measured by itsbinding ability in a functional ELISA. In a 100 μL reaction mixturecontaining biotinylated rmWnt-3a or rmWnt-5a at 50-100 ng/mL and rhFrizzled8/Fc Chimera dilutions at 0.1-8,000 ng/mL, the concentration of rhFrizzled8/ FcChimera that produces 50% of the optimal binding response is found to beapproximately 7-28 ng/mL.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE : 55-65 kDa, reducingconditions
Purity : >95%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
Reconstitution : Reconstitute at 500μg/mL in sterile PBS.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to-70 °C under sterile conditions after reconstitution.
PDBrendering based on 1ijy. :

Gene Name : FZD8 frizzled family receptor 8[ Homo sapiens ]
Official Symbol : FZD8
Synonyms : FZD8; frizzledfamily receptor 8; FZ-8; hFZ8; frizzled (Drosophila) homolog 8;frizzled 8, seven transmembrane spanning receptor; frizzled homolog 8(Drosophila); OTTHUMP00000019454; hFz8; Fz-8; frizzled-8; frizzledhomolog 8
Gene ID : 8325
mRNA Refseq : NM_031866
Protein Refseq : NP_114072
MIM : 606146
UniProt ID : Q9H461
Chromosome Location : 10p11.2
Pathway : Basal cellcarcinoma; Class B/2 (Secretin family receptors); GPCR ligand binding; HTLV-Iinfection; Melanogenesis; Pathways in cancer; Signal Transduction; Signalingby GPCR; Wnt Signaling Pathway; Wnt signaling network
Function : G-proteincoupled receptor activity; PDZ domain binding; Wnt-activated receptoractivity; Wnt-protein binding

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