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Recombinant Mouse Interleukin 23, Alpha Subunit P19

Cat. No.: Il23a-651M
Product Overview: RecombinantMouse Il23a protein was expressed in Spodopterafrugiperda. Met23-Ser335 (N-terminus), Leu20-Ala196 (C-terminus).
Description: Il23a isa heterodimeric cytokine composed of two disulfide-linked subunits, a p19subunit that is unique to Il23a, and a p40 subunit that is shared with IL-12.The Il23a homology to the p35 subunit of IL-12, as well as to other singlechain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to theextracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNAencodes a 196 amino acid residue (aa) precursor protein with a putative 19 aasignal peptide and 177 aa mature protein. Human and mouse Il23a share 70% aasequence identity. Although p19 is expressed by activated macrophages,dendritic cells, T cells, and endothelial cells, only activated macrophagesand dendritic cells express p40 concurrently to produce Il23a.
Source: Spodoptera frugiperda, Sf 21(baculovirus)-derived.
Form: Lyophilizedfrom a 0.2 um filtered solution in PBS with BSA as a carrier protein.
N-terminalSequence: Met23
MolecularWeight: 57 kDa
Activity: Measuredby its ability to induce IL-17 secretion by mouse splenocytes. The ED 50 for thiseffect is typically 0.05-0.25 ng/mL.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 66 kDa,reducing conditions.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 10μg/mL in sterile PBS containing at least 0.1% human or bovine serumalbumin.
Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Il23ainterleukin 23, alpha subunit p19 [ Mus musculus ]
Official Symbol: Il23a
Synonyms: Il23a; interleukin23, alpha subunit p19; p19; IL-23; interleukin-23 subunit alpha;IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin-23 subunit p19
Gene ID: 83430
mRNA Refseq: NM_031252
Protein Refseq: NP_112542
UniProt ID: Q9EQ14
Chromosome Location: 10
Pathway: Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway; Pertussis; Rheumatoidarthritis; Tuberculosis
Function: cytokine activity;contributes_to interleukin-23 receptor binding; protein binding

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