Active Recombinant Human Interleukin 34, His-tagged

• Cat.No.: IL34-652H
• Product Overview: RecombinantHuman IL34 protein was expressed in Murine myeloma cell line. Asn21-Pro242,with a C-terminal 6-His tag.

Specification

• Cat. No.: IL34-652H
• Description: IL34 issecreted as a homodimer consisting of 39 kDa monomers. It belongs to no knowncytokine family. Human IL34 is synthesized as a242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222aa mature chain. The mature chain contains one potential site of N-linkedglycosylation. Human IL34 is 71% identicaltomouse IL34 on theamino acid level. IL34 is expressed in various tissues, includingthe heart, brain, liver, kidney, spleen, thymus, testes, ovary, smallintestine, prostate, and colon, and is most abundant in the spleen.
• Source: Mammalian cells
• Form: Lyophilized from a0.2 um filtered solution in PBS and NaCl with BSA as a carrier protein.
• N-terminalSequence: Asn21
• MolecularWeight: 26.1 kDa
• Activity: Measuredin a cell proliferation assay using human peripheral blood monocytes. The ED 50for this effect is typically 0.75-3.75 ng/mL.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 35-38kDa, reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100μg/mL in sterile PBS containing at least 0.1% human or bovine serumalbumin.
• Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 monthsfrom date of receipt, -20 to -70°C as supplied. 3 months,-20to-70°C under sterile conditions after opening.

Gene Information

• Gene Name: IL34 interleukin 34 [ Homosapiens ]
• Official Symbol: IL34
• Synonyms: IL34; interleukin 34; IL-34; C16orf77; interleukin-34; chromosome 16 open reading frame 77; MGC34647
• Gene ID: 146433
• mRNA Refseq: NM_001172771
• Protein Refseq: NP_001166242
• MIM: 612081
• UniProt ID: Q6ZMJ4
• Chromosome Location: 16q22.1
• Function: cytokine activity;growth factor activity; macrophage colony-stimulating factor receptor binding

Reviews

05/10/2021

IL34 has shown good biocompatibility and safety in related experiments.

01/19/2020

When using IL34 for experiments, the experimental conditions and results are highly repeatable.

10/24/2019

Quality is stable and reliable, with no significant differences between batches.

Q&As

What is the effect of IL34 on tumor prognosis?

There are no clear studies showing the effect of IL34 on tumor prognosis.

What are the advantages of IL34 over other treatments?

Can fight disease by modulating the immune system and may have better efficacy and fewer side effects than other treatments.

What is the mechanism of action of IL34 in the treatment of tumor?

May inhibit tumor growth and metastasis by enhancing immune cells' ability to attack tumor cells.

How is the clinical trial of IL34 progressing?

No large-scale clinical trials have been reported, but some early studies have shown a potential therapeutic effect.

How does IL34 affect the immune system?

Regulate the function of macrophages and dendritic cells and affect the immune response of the immune system.

How to evaluate the efficacy of IL34?

The evaluation of the efficacy of IL34 usually requires a comprehensive evaluation of clinical symptoms, biochemical indicators, imaging and other indicators.