Active Recombinant Human Anti-Mullerian Hormone Receptor, Type II, Fc-tagged

• Cat.No.: AMHR2-5601H
• Product Overview: Recombinant Human AMHR2protein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (C-terminus) and Pro18-Ser144 (N-terminus).

Specification

• Cat. No.: AMHR2-5601H
• Description: Human AMHR2 is an 82kDa serine/threonine receptor with a single transmembrane domain that belongsto the family of type II receptors of the TGF β superfamily. The AMHR2precursor is 573 amino acids (aa) in length, with a 17 aa signal sequence, a127 aa extracellular region that also contains two potential Nlinkedglycosylation sites, a 26 aa transmembrane region, and a 403 aa cytoplasmicregion that contains the serine/threonine kinase domain.
• Source: Mammalian cells
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: Pro18
• Molecular Weight: 40.2 kDa
• Activity: Measuredby its ability to bind rhAMHR2 in afunctional ELISA.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 60-65kDa, reducing conditions
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100 μg/mL in PBS
• Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: AMHR2 anti-Mullerian hormonereceptor, type II [ Homo sapiens ]
• Official Symbol: AMHR2
• Synonyms: AMHR2; anti-Mullerianhormone receptor, type II; AMHR; MRII; MISR2; MISRII; anti-Muellerian hormonetype-2 receptor; AMH type II receptor; MIS type II receptor; anti-Muellerianhormone type II receptor; Mullerian inhibiting substance type II receptor; EC2.7.11.30; OTTHUMP00000242707; OTTHUMP00000242708; OTTHUMP00000242709
• Gene ID: 269
• mRNA Refseq: NM_001164690
• Protein Refseq: NP_001158162
• MIM: 600956
• UniProt ID: Q16671
• Chromosome Location: 12q13
• Pathway: ALK2 signalingevents; Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: ATP binding; hormonebinding; metal ion binding; nucleotide binding; receptor activity; transforminggrowth factor beta receptor activity