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Recombinant Mouse Erythropoietin Receptor, Fc-tagged

Cat. No.: Epor-461M
Product Overview: Recombinant Mouse Eporprotein was expressed in Murine myeloma cell line with the Fc part of human IgG1.Ala25-Pro249.
Description: Erythropoietin (Epo),a glycoprotein produced primarily by the kidney, is the principal factor thatregulates erythropoiesis by stimulating the proliferation and differentiationof erythroid progenitor cells. The biological effects of Epo are mediated by theEpor. A member of the hematopoietic growth factor receptor superfamily which includesIL2, IL3, IL4, IL5, IL6, IL7, GMCSF, GCSF, thrombopoietin, LIF, CNTF, growth hormone,and prolactin.
Source: Murine myeloma cell line,NS0-derived
Form: Lyophilized from a 0.2μm filtered solution in PBS, EDTA and CHAPS.
N-terminalSequence: Ala25
Molecular Weight: 51.3 kDa
Activity: Measuredby its ability to inhibit Epodependent proliferation of TF1 human erythroleukemiccells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50for this effect is typically 12.5-50 ng/mL in the presence of 16 ng/mL of rmEpo.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.
Gene Name: Epor erythropoietinreceptor [ Mus musculus ]
Official Symbol: Epor
Synonyms: Epor; erythropoietinreceptor; EPO-R
Gene ID: 13857
mRNA Refseq: NM_010149
Protein Refseq: NP_034279
UniProt ID: P14753
Chromosome Location: 9 A3; 9 5.0 cM
Pathway: Cytokine-cytokine receptorinteraction; EPO Receptor Signaling; Hematopoietic cell lineage; Jak-STAT signalingpathway; Kit Receptor Signaling Pathway
Function: cytokine receptor activity;erythropoietin receptor activity; identical protein binding; protein binding;receptor activity; transmembrane signaling receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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