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Recombinant Mouse Interleukin 1 Receptor Antagonist, His-tagged

Cat. No.: Il1rn-5593M
Product Overview: Recombinant mouse Il1rnprotein, fused to His-tag at N-terminus was expressed in E. coli and purifiedby using conventional chromatography techniques.
Description: Interleukin1 receptor antagonist (Il1rn), alsoknown as IL1-RA, is a member of the interleukin 1 cytokine family. IL1RN mayrepresent a reservoir of IL-1 inhibitors, released upon cell death, whosefunction is no limit the pro-inflammatory signals but most prominently bymononuclear phagocytes and keratinocytes. IL1RN is reported to be associatedwith increased risk of osteoporotic fractures and gastric cancer.
Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol.
Molecular Weight: 20.0 kDa(177aa), confirmed by MALDI-TOF.
Purity: > 95%by SDS-PAGE
Concentration: 1 mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMRPSGK RPCKMQAFRI WDTNQKTFYL RNNQLIAGYL QGPNIKLEEKIDMVPIDLHS VFLGIHGGKL CLSCAKSGDD IKLQLEEVNI TDLSKNKEEDKRFTFIRSEK GPTTSFESAA CPGWFLCTTL EADRPVSLTN TPEEPLIVTK FYFQEDQ
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: Il1rn interleukin 1 receptorantagonist [ Mus musculus ]
Official Symbol: Il1rn
Synonyms: Il1rn; interleukin 1 receptor antagonist;ICIL-1RA; IL1F3; IL1RA; MGC10430; DIRA; MVCD4; IL-1ra3; IL1RN (IL1F3);IL-1ra; F630041P17Rik; interleukin-1 receptor antagonist protein; IRAP;IL-1RN; IL1 inhibitor; intracellular IL-1 receptor antagonist type II;intracellular interleukin-1 receptor antagonist (icIL-1ra); type IIinterleukin-1 receptor antagonist; Anakinra; OTTHUMP00000162022;OTTHUMP00000162023; OTTHUMP00000162024; OTTHUMP00000203731
Gene ID: 16181
mRNA Refseq: NM_001039701
Protein Refseq: NP_001034790
UniProt ID: P25085
Chromosome Location: 2 A3; 2 10.0 cM
Pathway: IL-1 Signaling Pathway
Function: interleukin-1 Type I receptor antagonistactivity; interleukin-1 Type II receptor antagonist activity; interleukin-1receptor antagonist activity; interleukin-1 receptor binding; interleukin-1,Type I receptor binding; interleukin-1, Type II receptor binding; receptoractivity

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