Pig Myelin basic protein MBP-6948P

Pig Myelin basic protein

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Pig Myelin basic protein

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Cat. No. : MBP-6948P
Product Overview : Pig Myelinbasic protein, was highly Purified from porcinebrain by method of Määttä et al.
Description : MBP is a peripheralmembrane protein, and its interaction with lipids is generally believed to becritical for the formation and stability of the multilamellar myelin sheath.It has been identified as a Ca2+-calmodulin regulated agent foractin polymerization, tropomyosin and actomyosin function, tubulinstabilization, and clathrin assembley. MBP is generally considered to be theantigen responsible for autoimmunity in multiple sclerosis (MS) and it hasthe capability to induce experimental allergic encephalomyelitis (EAE). MBPis also an endogenous inhibitor of the high-affinity cannabinoid binding sitein the brain and a substrate for numerous protein kinases (MAPK,serine/threonine kinase, protein kinase C). MBP is also suggested to beinvolved in intracellular signalling and as cytoskeletal components.
Source : porcine brain
Appearance : White powder.
Purity : >95%(SDS-PAGE; Immunoblot)
Formulation : Lyophilized. Essentially salt-free
Reconstitution : Reconstitutewith distilled water
Storage : Stablefor at least 3 years when stored at +4°C. Reconstituted protein is stable forat least six months at -20°C and for at least 24 hours at +37°C in aqueoussolution.
Renderingof MBP from PDB 1BX2 :

Gene Name : MBP myelin basic protein [ Susscrofa ]
Official Symbol : MBP
Synonyms : MBP;myelin basic protein
Gene ID : 414286
mRNA Refseq : NM_001001546
Protein Refseq : NP_001001546
Chromosome Location : 1; 1 80cM

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