Rabbit Anti-Mouse Cystatin C Monoclonal Antibody


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Rabbit Anti-Mouse Cystatin C Monoclonal Antibody

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Cat.No. : CAB11520RM
Product Overview : Rabbit Monoclonal Antibody to Mouse Cystatin C
Antigen Description : Mouse Cystatin-C, also known as Cystatin-3, Neuroendocrine basic polypeptide, Post-gamma-globulin, and CST3, is a secreted type 2 cysteine proteinase inhibitors of the cystatin superfamily, and exerts actions on a variety of cysteine proteases including papain and Cathepsins B, H, K, L and S. As the most abundant extracellular inhibitor of cysteine proteases, Cystatin-C encoded by a housekeeping gene is found ubiquitously in all organs and biological fluids at high concentration levels. It has been shown that Cystatin-C binds amyloid-beta and reduces cerebral amyloid-beta deposition or inhibits its fibril formation in an APP-transgenic mouse model. Thus, a point mutation in this gene (Leu 68 to Gln) hsa been associated with a severe hereditary form of amyloid angiopathy. Studies have also investigated Cystatin-C as a marker of kidney function and thyroid dysfunction prior to creatinine, and could be a useful clinical tool to identify HIV-infected persons. In addition, Cystatin-C expression is up-regulated in malignance of certain tumor progression.
Specificity : Mouse Cystatin C / CST3. No cross-reactivity in ELISA with Human CST3; Human HPRG; Human KNG1; Human cell lysate (293 cell line);
Immunogen : Recombinant Mouse Cystatin C / CST3 Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Mouse
Clone : A042
Applications : WB; ELISA
Dilution : Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CST3 in WB.Using a DAB detection system, the detection limit for Mouse CST3 is approximately 0.5 ng/lane under non-reducing conditions and 0.25 ng/lane under reducing conditions.ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CST3. The detection limit for Mouse CST3 is approximately 0.00245 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse Cystatin C / CST3
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70°C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : Cst3 cystatin C [ Mus musculus ]
Official Symbol : Cst3
Synonyms : CST3; cystatin C; cystatin-C; cystatin 3; cystatin-3; CysC;
Gene ID : 13010
mRNA Refseq : NM_009976
Protein Refseq : NP_034106
Pathway : Salivary secretion, organism-specific biosystem; Salivary secretion, conserved biosystem;
Function : beta-amyloid binding; cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; peptidase inhibitor activity; protease binding;

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