|Product Overview:||Recombinant Human SRC(Met 1-Leu 536) fused with His/GST tag at N-terminal was expressed in Insect cells.|
|Description:||This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.|
|Predicted N Terminal:||Met|
|Form:||Supplied as sterile 50mM Tris, 100mM NaCl, pH 8.0, 20% gly, 0.3mM DTT|
|Bio-activity:||The specific activity was determined to be 27 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.|
|Molecular Mass:||The recombinant human SRC/GST chimera consists of 773 amino acids and has a calculated molecular mass of 87.7 KDa. It migrates as an approximately 81 KDa band in SDS-PAGE under non-reduced conditions.|
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Purity:||> 90 % as determined by SDS-PAGE|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70 centigrade|
|Storage:||Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Shipping:||Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
Shipment made at ambient temperature may seriously affect the activity of the ordered products.
|Gene Name:||SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens ]|
|Synonyms:||ASV; SRC1; THC6; c-SRC; p60-Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog|
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