"RNF4" Related Products

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Recombinant Human Ring Finger Protein 4, His-tagged

Cat.No.: RNF4-7193H
Product Overview: Recombinant human RNF4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 23.7 kDa.
Description: E3 ubiquitin ligase RNF4, also known as RNF4, contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.5) containing 0.2M NaCl, 30% glycerol, 1mM DTT.
Molecular Mass: 23.7 kDa (213aa) confirmed by MALDI-TOF.
Protein length: 1-190aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMSTRKRR GGAINSRQAQ KRTREATSTP EISLEAEPIE LVETAGDEIV DLTCESLEPV VVDLTHNDSV VIVDERRRPR RNARRLPQDH ADSCVVSSDD EELSRDRDVY VTTHTPRNAR DEGATGLRPS GTVSCPICMD GYSEIVQNGR LIVSTECGHV FCSQCLRDSL KNANTCPTCR KKINHKRYHP IYI
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration: 0.5 mg/ml (determined by Bradford assay)
Gene Name: RNF4 ring finger protein 4 [ Homo sapiens ]
Official Symbol: RNF4
Synonyms: RNF4; ring finger protein 4; SLX5; SNURF; RES4-26; E3 ubiquitin-protein ligase RNF4; E3 ubiquitin ligase RNF4; small nuclear RING finger protein; EC=6.3.2; Protein SNURF
Gene ID: 6047
mRNA Refseq: NM_002938
Protein Refseq: NP_002929
MIM: 602850
UniProt ID: P78317
Chromosome Location: 4p16.3
Pathway: Adaptive Immune System, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem
Function: DNA binding; SUMO polymer binding; androgen receptor binding; nucleosome binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription factor binding; ubiquitin-protein ligase activity; zinc ion binding

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