Recombinant Human Ring Finger Protein 4, His-tagged RNF4-7193H

Recombinant Human Ring Finger Protein 4, His-tagged

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Recombinant Human Ring Finger Protein 4, His-tagged

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Cat.No. : RNF4-7193H
Product Overview : Recombinant human RNF4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 23.7 kDa.
Description : E3 ubiquitin ligase RNF4, also known as RNF4, contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.5) containing 0.2M NaCl, 30% glycerol, 1mM DTT.
Molecular Mass : 23.7 kDa (213aa) confirmed by MALDI-TOF.
Protein length : 1-190aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMSTRKRR GGAINSRQAQ KRTREATSTP EISLEAEPIE LVETAGDEIV DLTCESLEPV VVDLTHNDSV VIVDERRRPR RNARRLPQDH ADSCVVSSDD EELSRDRDVY VTTHTPRNAR DEGATGLRPS GTVSCPICMD GYSEIVQNGR LIVSTECGHV FCSQCLRDSL KNANTCPTCR KKINHKRYHP IYI
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name : RNF4 ring finger protein 4 [ Homo sapiens ]
Official Symbol : RNF4
Synonyms : RNF4; ring finger protein 4; SLX5; SNURF; RES4-26; E3 ubiquitin-protein ligase RNF4; E3 ubiquitin ligase RNF4; small nuclear RING finger protein; EC=6.3.2; Protein SNURF
Gene ID : 6047
mRNA Refseq : NM_002938
Protein Refseq : NP_002929
MIM : 602850
UniProt ID : P78317
Chromosome Location : 4p16.3
Pathway : Adaptive Immune System, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem
Function : DNA binding; SUMO polymer binding; androgen receptor binding; nucleosome binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription factor binding; ubiquitin-protein ligase activity; zinc ion binding

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