Active Recombinant Human InsR, GST-tagged
Cat.No. : | INSR-1416H |
Product Overview : | Recombinant human InsR (1011-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | InsR is the insulin receptor tyrosine kinase that is involved in insulin signaling. InsR is post-translationally cleaved into two chains, α and β? that are covalently linked. Binding of insulin to the InsR stimulates glucose uptake. Insulin receptor signaling helps to maintain fuel homeostasis and prevent diabetes. Studies have shown that a conditional knockout of insulin receptor substrate 2 (IRS2) in mouse pancreas β cells and parts of the brain--including the hypothalamus--increased appetite, lean and fat body mass, linear growth, and insulin resistance that progressed to diabetes. InsR signaling also increases the regeneration of adult β cells and the central control of nutrient homeostasis. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 2683 nmol/min/mg |
Molecular Mass : | ~70 kDa |
Protein length : | 1011 aa-end |
Purity : | >80% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | INSR insulin receptor [ Homo sapiens ] |
Official Symbol : | INSR |
Synonyms : | INSR; insulin receptor; CD220; IR; HHF5; |
Gene ID : | 3643 |
mRNA Refseq : | NM_000208 |
Protein Refseq : | NP_000199 |
MIM : | 147670 |
UniProt ID : | P06213 |
Chromosome Location : | 19p13.3-p13.2 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; IRS activation, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem; |
Function : | 3-phosphoinositide-dependent protein kinase binding; ATP binding; GTP binding; PTB domain binding; SH2 domain binding; insulin binding; insulin binding; insulin binding; insulin receptor substrate binding; insulin-activated receptor activity; insulin-like growth factor I binding; insulin-like growth factor II binding; insulin-like growth factor receptor binding; lipoic acid binding; nucleotide binding; phosphatidylinositol 3-kinase binding; protein binding; protein complex binding; protein domain specific binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
INSR-3163H | Recombinant Human INSR Protein, His (Fc)-Avi-tagged | +Inquiry |
INSR-1260H | Recombinant Human INSR Protein, His-SUMO-tagged | +Inquiry |
INSR-2564H | Recombinant Human INSR protein(601-750 aa), C-His-tagged | +Inquiry |
INSR-4564M | Recombinant Mouse INSR Protein, His (Fc)-Avi-tagged | +Inquiry |
INSR-5092H | Recombinant Human INSR Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
INSR-474HCL | Recombinant Human INSR cell lysate | +Inquiry |
INSR-2648HCL | Recombinant Human INSR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1607 | INSR Internalization Assay Kit | +Inquiry |
Kit-1605 | U2OS INSR Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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