"KAT2B" Related Products


Recombinant Human KAT2B , GST-tagged

Cat.No.: KAT2B-6953H
Product Overview: Recombinant human KAT2B (PCAF) (431-end; contains the catalytic domain) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: KAT2B (also known as PCAF) is a transcription cofactor with a histone acetyltransferase (HAT) activity. KAT2B protein associates with p300/CBP which is a large nuclear protein that bind to many sequence-specific factors that are involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. KAT2B has histone acetyl transferase activity with core histones and nucleosome core particles indicating that KAT2B plays a direct role in transcriptional regulation. PCAF functions as a coordinating factor in the regulation of HIF1A-mediated apoptosis and p53-dependent cell cycle progression.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~70 kDa
Protein length: 431 aa-end; contains the catalytic domain
Purity: >95%
Applications: Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1 μg/μ
Gene Name: KAT2B K(lysine) acetyltransferase 2B [ Homo sapiens ]
Official Symbol: KAT2B
Synonyms: KAT2B; K(lysine) acetyltransferase 2B; p300/CBP associated factor , PCAF; histone acetyltransferase KAT2B; GCN5; GCN5L; P/CAF; histone acetylase PCAF; CREBBP-associated factor; p300/CBP-associated factor; lysine acetyltransferase 2B; histone acetyltransferase PCAF; P; CAF; PCAF;
Gene ID: 8850
mRNA Refseq: NM_003884
Protein Refseq: NP_003875
MIM: 602303
UniProt ID: Q92831
Chromosome Location: 3p24
Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; HTLV-I infection, organism-specific biosystem;
Function: acetyltransferase activity; cyclin-dependent protein kinase inhibitor activity; histone acetyltransferase activity; histone deacetylase binding; lysine N-acetyltransferase activity; lysine N-acetyltransferase activity; protein binding; protein kinase binding; transcription coactivator activity; transcription cofactor activity; transcription factor binding; transferase activity, transferring acyl groups;

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