"IRAK3" Related Products


Recombinant Human IRAK3, GST-tagged

Cat.No.: IRAK3-7003H
Product Overview: Recombinant full-length human IRAK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: IRAK3 or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which is essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAKM mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~96 kDa
Protein length: Full length
Purity: >80%
Applications: Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: IRAK3 interleukin-1 receptor-associated kinase 3 [ Homo sapiens ]
Official Symbol: IRAK3
Synonyms: IRAK3; interleukin-1 receptor-associated kinase 3; IRAK M; IL-1 receptor-associated kinase M; ASRT5; IRAKM; FLJ13601;
Gene ID: 11213
mRNA Refseq: NM_001142523
Protein Refseq: NP_001135995
MIM: 604459
UniProt ID: Q9Y616
Chromosome Location: 12q13.13
Pathway: Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem;
Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity;

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