Recombinant Human GP9, His-tagged

• Cat.No.: GP9-7219H

Specification

• product overview: Recombinant human GP9 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• description: GP9 is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.
• source: E. coli
• species: Human
• tag: His
• form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2M UREA, 10% glycerol
• molecular mass: 16.8 kDa (154aa)
• protein length: 17-147aa
• aa sequence: MGSSHHHHHH SSGLVPRGSH MGSTKDCPSP CTCRALETMG LWVDCRGHGL TALPALPART RHLLLANNSL QSVPPGAFDH LPQLQTLDVT QNPWHCDCSL TYLRLWLEDR TPEALLQVRC ASPSLAAHGP LGRLTGYQLG SCGWQLQASW VRPG
• purity: >90% by SDS - PAGE
• applications: SDS-PAGE
• storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• concentration: 1 mg/ml

Gene Information

• gene name: GP9 glycoprotein IX (platelet) [ Homo sapiens ]
• official symbol: GP9
• synonyms: GP9; glycoprotein IX (platelet); platelet glycoprotein IX; CD42a; GPIX; GP-IX; glycoprotein 9
• Gene ID: 2815
• mrna refseq: NM_000174
• protein refseq: NP_000165
• mim: 173515
• uniprot id: P14770
• chromosome location: 3q21.3
• pathway: ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GP1b-IX-V activation signalling, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Hemostasis, organism-specific biosystem