Recombinant Human GREM1, His-tagged
Cat.No. : | GREM1-7261H |
- Specification
- Gene Information
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product overview : | Recombinant human GREM1 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
description : | GREM1 is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this protein belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this protein may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
source : | E. coli |
species : | Human |
tag : | His |
form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol |
molecular mass : | 20.7 kDa (183aa) |
protein length : | 25-184aa |
aa sequence : | MGSSHHHHHH SSGLVPRGSH MGSKKKGSQG AIPPPDKAQH NDSEQTQSPQ QPGSRNRGRG QGRGTAMPGE EVLESSQEAL HVTERKYLKRDWCKTQPLKQ TIHEEGCNSR TIINRFCYGQ CNSFYIPRHI RKEEGSFQSC SFCKPKKFTT MMVTLNCPEL QPPTKKKRVT RVKQCRCISI DLD |
purity : | >90% by SDS - PAGE |
applications : | SDS-PAGE |
storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
concentration : | 0.5 mg/ml |
gene name : | GREM1 gremlin 1 [ Homo sapiens ] |
official symbol : | GREM1 |
synonyms : | GREM1; gremlin 1; CKTSF1B1, cysteine knot superfamily 1, BMP antagonist 1 , gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-1; DAND2; DRM; gremlin; gremlin 1-like protein; DAN domain family member 2; increased in high glucose-2; proliferation-inducing gene 2; increased in high glucose protein 2; cell proliferation-inducing gene 2 protein; cysteine knot superfamily 1, BMP antagonist 1; gremlin 1, cysteine knot superfamily, homolog; down-regulated in Mos-transformed cells protein; PIG2; IHG-2; GREMLIN; CKTSF1B1; MGC126660; |
Gene ID : | 26585 |
mrna refseq : | NM_001191322 |
protein refseq : | NP_001178251 |
mim : | 603054 |
uniprot id : | O60565 |
chromosome location : | 15q13.3 |
pathway : | BMP receptor signaling, organism-specific biosystem; |
function : | cytokine activity; protein binding; |
Products Types
◆ Recombinant Protein | ||
Grem1-315M | Recombinant Mouse Grem1 Protein, His-tagged | +Inquiry |
GREM1-2215H | Recombinant Human GREM1 Protein, His-tagged | +Inquiry |
GREM1-19H | Recombinant Human/Bovine/Porcine GREM1 Protein | +Inquiry |
GREM1-494H | Recombinant Human GREM1 Protein | +Inquiry |
GREM1-2342R | Recombinant Rat GREM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
GREM1-001MCL | Recombinant Mouse GREM1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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