Recombinant Human CD-95, His Tag

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Recombinant Human CD-95, His Tag

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Cat. No. : CDA074P
Product Overview : Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids. The FAS antigen is purified by proprietary chromatographic techniques.
Description : FAS/CD95 is a 36kDa transmembrane type I receptor, which belongs to the NF/NGF receptor super-family. It is a potent inducer of apoptosis in cells of the immune system upon interaction with its natural ligand, CD95L. Although the CD95/CD95L system could play a role in tumor regression, tumor cells seem to down-regulate CD95 expression as a mechanism of resistance to CD95L-induced killing by T lymphocytes and NK cells. The Fas antigen is expressed on the surface of various cell types, including activated T and B lymphocytes and T lymphoblastoid cell line. CD95 is also expressed in a broad panel of non-transformed cells outside the immune system.
Source : Escherichia Coli.
Physical Appearance : Sterile liquid formulation.
Purity : Greater than 95% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : 8M urea, 20mM Tris-HCl, pH-8.0, 0.2M Imidazole, 0.01M β-ME.
Storage : CD95 although stable at 10°C for 5 days, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Synonyms : CD95; CD-95; Tumor necrosis factor receptor superfamily member 6; FASLG receptor; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; CD95 antigen; FAS; APT1; FAS1; TNFRSF6; APO-1; FASTM; ALPS1A; CD95; Fas (TNF receptor superfamily, member 6); tumor necrosis factor receptor superfamily, member 6; Fas AMA; Fas antigen; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000059646; apoptosis antigen 1; APO-1 cell surface antigen; tumor necrosis factor receptor superfamily member 6; FAIM2; LFG; NMP35; Apoptosis-mediating surface antigen FAS; FASLG receptor; Fas (TNF receptor superfamily, member 6).
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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