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Mouse Anti-Atg3 Monoclonal Antibody

Cat.No. : DMABT-H17736
Product Overview : Mouse Anti-Atg3 Monoclonal Antibody
  • Specification
  • Gene Information
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Antigen Description : Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Microtubule-associated protein light chain4(LC3) is a homologue of yeast Atg8, an essential component of autophagy. Following synthesis, the C-terminus of LC3 is cleaved by a cysteine protease-Atg4, to produce LC3-I, which is located in cytosolic fraction. LC3-I is activated by the E1-like enzyme Atg7 and forms a Atg7-LC3-I thioester. Atg7-LC3-I is transferred to Atg3 to form Atg3-LC3-I thioester. Atg3 is an E2-like enzyme that catalyzes the conjugation of LC3-I and phosphatidylethanolamine (PE) to form LC3-II. The LC3-II-PE conjugate is essential for binding tightly to autophagosomal membrane.
Target : Atg3
Host : Mouse
Isotype : IgG2b
species : Human
Clone : 4F9
Conjugation : N/A
Applications : WB,IP,ICC,IHC,Flow Cyt
Storage : -20°C
Size : 100 μg
Ship : 4°C
Gene Name : ATG3 ATG3 autophagy related4homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol : Atg3
Synonyms : ATG3; ATG3 autophagy related4homolog (S. cerevisiae); APG3 autophagy4like (S. cerevisiae) , APG3L; ubiquitin-like-conjugating enzyme ATG3; DKFZp564M1178; FLJ22125; MGC15201; PC3 96; hApg3; 2610016C12Rik; autophagy-related protein 3; APG3; APG3L; PC3-96; APG3-LIKE;
Gene ID : 64422
mRNA Refseq : NM_022488
Protein Refseq : NP_071933
MIM : 609606
UniProt ID : Q9NT62
Chromosome Location : 3q13.2
Pathway : Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem;
Function : Atg12 ligase activity; Atg8 ligase activity; enzyme binding; ligase activity; protein binding; small conjugating protein ligase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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