"TNNI3" Related Products


Native Human TNNI3

Cat. No.: TNNI3-221H
Product Overview: Native Human TNNI3 was purified from Human cardiac tissue by Tn-C affinity chromatography.
Description: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Source: Human cardiac tissue
Molecular Mass: 24 KDa
Formulation: Liquid
Storage buffer: 8 M Urea, 50 mM Tris.HCl, 15 mM ß-mercaptoethanol, 1 mM EDTA (pH 8.0)
Applications: This peptide can be used with studies using ab7829, ab8290, ab8291 and ab137719.
Biological activity: SDS PAGE profile of a typical recombinant Troponin-I preparation (3.8ug) showed a major band at 24kDa and a minor band attributable to Troponin-I dimer. Please note: Troponin-I is very susceptible to proteolytic breakdown within cardiac tissue and it is difficult to isolate undegraded native human cardiac troponin-I. This product is greater than 70% intact and hence proteolytic fragments can be observed.
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
OfficialSymbol: TNNI3
Gene Name: TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ]
Synonyms: TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; MGC116817; TNNI3; troponin I, cardiac; Troponin I, cardiac muscle; Cardiac troponin I; familial hypertrophic cardiomyopathy 7
Gene ID: 7137
mRNA Refseq: NM_000363
Protein Refseq: NP_000354
MIM: 191044
UniProt ID: P19429
Chromosome Location: 19q13.4
Pathway: Hypertrophic cardiomyopathy (HCM); Muscle contraction; Cardiac muscle contraction
Function: actin binding; calcium-dependent protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding; calcium channel inhibitor activity

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