Native Human TNNI3

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Native Human TNNI3

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Cat. No. : TNNI3-221H
Product Overview : Native Human TNNI3 was purified from Human cardiac tissue by Tn-C affinity chromatography.
Description : Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Source : Human cardiac tissue
Molecular Mass : 24 KDa
Formulation : Liquid
Storage buffer : 8 M Urea, 50 mM Tris.HCl, 15 mM ß-mercaptoethanol, 1 mM EDTA (pH 8.0)
Applications : This peptide can be used with studies using ab7829, ab8290, ab8291 and ab137719.
Biological activity : SDS PAGE profile of a typical recombinant Troponin-I preparation (3.8ug) showed a major band at 24kDa and a minor band attributable to Troponin-I dimer. Please note: Troponin-I is very susceptible to proteolytic breakdown within cardiac tissue and it is difficult to isolate undegraded native human cardiac troponin-I. This product is greater than 70% intact and hence proteolytic fragments can be observed.
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
OfficialSymbol : TNNI3
PDB rendering basedon 1j1d. :

Gene Name : TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ]
Synonyms : TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; MGC116817; TNNI3; troponin I, cardiac; Troponin I, cardiac muscle; Cardiac troponin I; familial hypertrophic cardiomyopathy 7
Gene ID : 7137
mRNA Refseq : NM_000363
Protein Refseq : NP_000354
MIM : 191044
UniProt ID : P19429
Chromosome Location : 19q13.4
Pathway : Hypertrophic cardiomyopathy (HCM); Muscle contraction; Cardiac muscle contraction
Function : actin binding; calcium-dependent protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding; calcium channel inhibitor activity

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