"MAP4K2" Related Products

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Recombinant Human MAP4K2, GST-tagged

Cat. No. : MAP4K2-934H
Product Overview : Recombinant full-length human MAP4K2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag
Description : MAP4K2 is a serine/threonine protein kinase that is activated by TNFμ and interacts with the TNF receptor-associated factor 2 (TRAF2). MAP4K2 is upstream of MAP kinases and particularly activates the SAPK pathway . Although MAP4K2 is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to MAP4K2 can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/MAP4K2 may modulate secretion in response to stress stimuli .
Expression System : Sf9 insect cells using baculovirus
Species : Human
Sequence : Full-length
Purity : >80%
Concentration : 0.1ug/ul
Applications : Kinase Assay, Western Blot
Molecular Weight : ~125 kDa
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Homo sapiens ]
Official Symbol : MAP4K2
Synonyms : mitogen-activated protein kinase kinase kinase kinase 2; MAPK/ERK kinase kinase kinase 2; GCK; MEK kinase kinase 2; RAB8IP; MEKKK 2; BL44; EC 2.7.11.1; B lymphocyte serine/threonine-protein kinase; B lymphocyte serine/threonine protein kinase; Germinal center kinase; germinal centre kinase (GC kinase); Rab8-interacting protein; Rab8 interacting protein; GC kinase
Gene ID : 5871
mRNA Refseq : NM_004579
Protein Refseq : NP_004570
MIM : 603166
UniProt ID : Q12851
Chromosome Location : 11q13
Pathway : Insulin Signaling; organism-specific biosystem; MAPK signaling pathway; conserved biosystem; TNF receptor signaling pathway
Function : ATP binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity

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