"IGLL1" Related Products

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Recombinant Human IGLL1, His-tagged

Cat.No.: IGLL1-7554H
Product Overview: Recombinant human IGLL1protein, fused to His-tag at N-terminus, was expressed in E.coli.
Antigen Description: The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. IGLL1 is one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Molecular Mass: 21.5 kDa (199aa)
Protein length: 38-213aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSLLRPTAA SQSRALGPGA PGGSSRSSLR SRWGRFLLQR GSWTGPRCWP RGFQSKHNSV THVFGSGTQL TVLSQPKATP SVTLFPPSSE ELQANKATLV CLMNDFYPGI LTVTWKADGT PITQGVEMTT PSKQSNNKYA ASSYLSLTPE QWRSRRSYSC QVMHEGSTVE KTVAPAECS
Purity: >85% as determined by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml
Gene Name: IGLL1 immunoglobulin lambda-like polypeptide 1 [ Homo sapiens ]
Official Symbol: IGLL1
Synonyms: IGLL1; immunoglobulin lambda-like polypeptide 1; IGLL; 14.1; CD179B; IGL5; IGVPB; lambda5; ig lambda-5; CD179b antigen; CD179 antigen-like family member B; Pre-B lymphocyte-specific protein-2; immunoglobulin-related 14.1 protein; immunoglobulin-related protein 14.1; immunoglobulin omega polypeptide chain; IGO; AGM2; IGL1; CD179b; VPREB2; IGLJ14.1;
Gene ID: 3543
mRNA Refseq: NM_020070
Protein Refseq: NP_064455
MIM: 146770
UniProt ID: P15814
Chromosome Location: 22q11.23
Pathway: Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem;

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