| Antigen Description : |
Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation. |
| specificity : |
It specifically recognises mouse Tim-2 (T-cell immunoglobulin mucin 2), a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells. |
| Target : |
Timd2 |
| Immunogen : |
Tim-2-Ig, consisting of amino acids 1-230 of mouse Tim-2, coupled with the Fc portion of mouse IgG2a. |
| Host : |
Rat |
| Isotype : |
IgG2a |
| species : |
Mouse |
| Clone : |
SNU3-36 |
| Purification : |
Purified IgG |
| Conjugation : |
N/A |
| Applications : |
Flow Cyt,IP,WB |
| Dilution : |
Flow Cytometry:1/25 - 1/200 |
| Preparation : |
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Protein Concentration : |
1 mg/ml |
| Storage : |
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Preservative : |
0.09% Sodium Azide (NaN3) |
| Shelf life : |
18 months from date of despatch. |
| Size : |
0.1 mg |
