Cat. No. : |
BMP2-30H |
Description : |
BMP2 is a member of the BMP subgroup belonging to the transforming growth factor superfamily. The mature BMP2 acts as disulfide-linked homodimers and heterodimers with BMP7 after proteolytic removal of propeptide. BMP2 is capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. |
Source : |
Human |
Host : |
Native |
Form : |
Supplied as a 0.2 μm filtered solution of 40% acetonitrile + 0.1% TFA. |
Purity : |
> 98 % as determined by SDS-PAGE |
Bio-activity : |
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5 - 0.9 μg / ml. |
Endotoxin : |
< 1.0 EU per μg protein as determined by the LAL method |
Stability : |
Samples are stable for up to twelve months from date of receipt at -70°C. |
Predicted N terminal : |
Met |
Molecular Mass : |
The recombinant human BMP2 monomer consists of 115 amino acids and has a predicted molecular mass of 13 kDa. It migrates with the apparent molecular mass of 13 & 26 kDa corresponding to the monomer & homodimer in SDS-PAGE under reducing conditions. |
Storage : |
Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
Pathways : |
Adipogenesis; Basal cell carcinoma; Cytokine-cytokine receptor interaction; Heart Development; Hedgehog signaling pathway; Id Signaling Pathway; Pathways in cancer; Senescence and Autophagy; Signaling by BMP; TGF-beta signaling pathway |