Human BMP2 BMP2-30H

Human BMP2

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Human BMP2

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Cat. No. : BMP2-30H
Product Overview : A DNA sequence encoding the mature form of human BMP2 ( NP_001191.1 ) ( Gln283 - Arg396 ) was expressed.
Description : BMP2 is a member of the BMP subgroup belonging to the transforming growth factor superfamily. The mature BMP2 acts as disulfide-linked homodimers and heterodimers with BMP7 after proteolytic removal of propeptide. BMP2 is capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines.
Source : Human
Host : Native
Form : Supplied as a 0.2 μm filtered solution of 40% acetonitrile + 0.1% TFA.
Purity : > 98 % as determined by SDS-PAGE
Bio-activity : Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5 - 0.9 μg / ml.
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal : Met
Molecular Mass : The recombinant human BMP2 monomer consists of 115 amino acids and has a predicted molecular mass of 13 kDa. It migrates with the apparent molecular mass of 13 & 26 kDa corresponding to the monomer & homodimer in SDS-PAGE under reducing conditions.
Storage : Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Pathways : Adipogenesis; Basal cell carcinoma; Cytokine-cytokine receptor interaction; Heart Development; Hedgehog signaling pathway; Id Signaling Pathway; Pathways in cancer; Senescence and Autophagy; Signaling by BMP; TGF-beta signaling pathway
PDBrendering based on 3bmp :

Gene Name : BMP2 bone morphogenetic protein 2 [ Homo sapiens ]
Official Symbol : BMP2
Synonyms : BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; OTTHUMP00000030228; bone morphogenetic protein 2A; Bone morphogenetic protein 2; Bone morphogenetic protein 2A
Gene ID : 650
mRNA Refseq : NM_001200
Protein Refseq : NP_001191
MIM : 112261
UniProt ID : P12643
Chromosome Location : 20p12
Function : receptor activity; protein binding; BMP receptor binding; activin receptor activity; growth factor activity; SMAD binding; cytokine activity; phosphatase activator activity; protein domain specific binding; protein heterodimerization activity; transforming growth factor beta receptor binding; transmembrane receptor protein serine/threonine kinase activity

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