Human BMP2


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Human BMP2

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Cat. No. : BMP2-30H
Product Overview : A DNA sequence encoding the mature form of human BMP2 ( NP_001191.1 ) ( Gln283 - Arg396 ) was expressed.
Description : BMP2 is a member of the BMP subgroup belonging to the transforming growth factor superfamily. The mature BMP2 acts as disulfide-linked homodimers and heterodimers with BMP7 after proteolytic removal of propeptide. BMP2 is capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines.
Source : Human
Host : Native
Form : Supplied as a 0.2 μm filtered solution of 40% acetonitrile + 0.1% TFA.
Purity : > 98 % as determined by SDS-PAGE
Bio-activity : Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5 - 0.9 μg / ml.
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal : Met
Molecular Mass : The recombinant human BMP2 monomer consists of 115 amino acids and has a predicted molecular mass of 13 kDa. It migrates with the apparent molecular mass of 13 & 26 kDa corresponding to the monomer & homodimer in SDS-PAGE under reducing conditions.
Storage : Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Pathways : Adipogenesis; Basal cell carcinoma; Cytokine-cytokine receptor interaction; Heart Development; Hedgehog signaling pathway; Id Signaling Pathway; Pathways in cancer; Senescence and Autophagy; Signaling by BMP; TGF-beta signaling pathway
PDBrendering based on 3bmp :

Gene Name : BMP2 bone morphogenetic protein 2 [ Homo sapiens ]
Official Symbol : BMP2
Synonyms : BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; OTTHUMP00000030228; bone morphogenetic protein 2A; Bone morphogenetic protein 2; Bone morphogenetic protein 2A
Gene ID : 650
mRNA Refseq : NM_001200
Protein Refseq : NP_001191
MIM : 112261
UniProt ID : P12643
Chromosome Location : 20p12
Function : receptor activity; protein binding; BMP receptor binding; activin receptor activity; growth factor activity; SMAD binding; cytokine activity; phosphatase activator activity; protein domain specific binding; protein heterodimerization activity; transforming growth factor beta receptor binding; transmembrane receptor protein serine/threonine kinase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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