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| Cat. No.: | CSF2-648C |
| Product Overview: | GMCSF Canine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 128 amino acids and having a molecular mass of 14.2 kDa. GM-CSF is purified by proprietary chromatographic techniques. |
| Description: | GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. |
| Source: | Canine |
| Host: | Escherichia Coli. |
| Form: | GMCSF was lyophilized after extensive dialysis against 1x PBS pH= 7.4μ0.1. |
| Purity: | Greater than 96.0% as determined by 1. Analysis by RP-HPLC. 2. Analysis by SDS-PAGE. |
| Bio-activity: | The ED50 as calculated by the dose-dependant stimulation of the proliferation of human TF1 erythroleukemic cells is typically 1-4 ng/ml. |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Solubility: | It is recommended to reconstitute the lyophilized GMCSF in sterile deionized water not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Amino acid sequence: | APTRSPTLVT RPSQHVDAIQ EALSLLNNSN DVTAVMNKAV KVVSEVFDPE GPTCLETRLQ LYKEGLQGSL TSLKNPLTMM ANHYKQHCPP TPESPCATQN INFKSFKENL KDFLFNIPFD CWKPVKK. |
| Storage: | It is recommended to reconstitute the lyophilized GMCSF in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Gene Name: | CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Canis lupus familiaris ] |
| Official Symbol: | CSF2 |
| Synonyms: | CSF2; GM-CS; granulocyte-macrophage colony-stimulating factor; CSF; colony-stimulating factor |
| Gene ID: | 403923 |
| mRNA Refseq: | NM_001003245 |
| Protein Refseq: | NP_001003245 |
| UniProt ID: | P48749 |
| Pathway: | Amoebiasis; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; HTLV-I infection; Hematopoietic cell lineage; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Rheumatoid arthritis; T cell receptor signaling pathway |
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