"FAP" Related Products

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Recombinant Human fibroblast activation protein, alpha, GST-tagged

Cat. No.: FAP-1461H
Product Overview: Seprase Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 203 amino acids (559-761 a.a.) and having a total Mw of 48kDa. Seprase is fused to a GST tag and is purified by proprietary chromatographic techniques.
Description: Seprase is a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. Seprase is a homodimeric integral membrane gelatinase, which is part of the serine protease family. Seprase is expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. Seprase protein has a role in the control of fibroblast growth or epithelial-mesenchymal interactions throughout development, tissue repair, and epithelial carcinogenesis.
Source: Human
Host: Escherichia Coli
Form: Seprase is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Physical Appearance: Sterile Filtered clear solution.
Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name: FAP fibroblast activation protein, alpha [ Homo sapiens ]
Official Symbol: FAP
Synonyms: FAP; fibroblast activation protein, alpha; FAPA; DPPIV; DKFZp686G13158; seprase; OTTHUMP00000204566; OTTHUMP00000207304; integral membrane serine protease; 170 kDa melanoma membrane-bound gelatinase
Gene ID: 2191
mRNA Refseq: NM_004460
Protein Refseq: NP_004451
MIM: 600403
UniProt ID: Q12884
Chromosome Location: 2q23
Function: metalloendopeptidase activity; metalloendopeptidase activity; peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; contributes_to serine-type peptidase activity; serine-type peptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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