Recombinant Human Interleukin 19 IL19-499H

Recombinant Human Interleukin 19

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Recombinant Human Interleukin 19

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Cat. No. : IL19-499H
Product Overview : Recombinant Human IL-19 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids and having a molecular mass of 17913 Dalton.
Description : Interleukin-19 (IL-19) is a novel cytokine that was initially identified during a sequence data base search aimed at finding potential Interleukin-10 homologs. Interleukin-19 shares 21% amino acid identity with IL-10.
Species : Human
Source : E.coli
Form : Lyophilized from a concentrated (1mg/ml) solution in water containing 10mM sodium citrate pH-5.
Purity : Purity Greater than 98% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Bio-activity : Recombinant Human Interleukin-19 is fully biologically active when compared to standard. The activity is determined by it"s ability to activate STAT following receptor-ligand interaction.
Physical Appearance : Sterile Filtered white lyophilized (freeze-dried) powder.
Solubility : Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg"s/ml, which can be further diluted into other aqueous solutions.
Purity Greater than 98% as determined by : Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE.
Protein Content determined by : UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
Endotoxin Level : Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Amino acid sequence : MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH
Storage : Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Pathways : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Crystalstructure of human IL-19. :

Gene Name : IL19 interleukin 19 [ Homo sapiens ]
Official Symbol : IL19
Synonyms : IL19; interleukin 19; MDA1; NG.1; ZMDA1; IL-10C; melanoma differentiation associated protein-like protein; Interleukin-19; IL-19; Melanoma differentiation-associated protein-like protein
Gene ID : 29949
mRNA Refseq : NM_013371
Protein Refseq : NP_037503
MIM : 605687
UniProt ID : Q9UHD0
Chromosome Location : 1q32.2
Function : cytokine activity

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