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Recombinant Human Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)

Cat.No. : ITGAM-4257H
Product Overview : CD11b Human Recombinant (aa 936-1154) expressed in E.coli, shows a 52 kDa band on SDS-PAGE. The CD11b is purified by proprietary chromatographic techniques.
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Cat. No. : ITGAM-4257H
Description : Leukocyte associated protein consists of two polypeptide chains with molecular weights 95 and 170kDa. The moleculae functions as a cell surface receptor for the C3bi complement fragment. It belongs to family of heterodimeric proteins (designated CD11) which share a common beta chain CD18 of 95kDa. The alpha chain component of the leukocyte associated antigen is expressed on granulocytes, monocytes and macrophages.
Source : Human
Host : Escherichia Coli.
Form : CD11b in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Physical Appearance : Sterile Filtered clear solution.
Storage : Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Gene Name : ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) [ Homo sapiens ]
Official Symbol : ITGAM
Synonyms : ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit); CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; MGC117044; integrin alpha M; antigen CD11b (p170); macrophage antigen alpha polypeptide; neutrophil adherence receptor alpha-M subunit; CD11b; CD11 antigen-like family member B; CD11b antigen; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; integrin, alpha M (complement component 3 receptor 3 subunit); integrin, alpha M (complement component receptor 3, alpha; CD11b (p170), macrophage antigen alpha polypeptide); Integrin alpha-M
Gene ID : 3684
mRNA Refseq : NM_000632
Protein Refseq : NP_000623
MIM : 120980
UniProt ID : P11215
Chromosome Location : 16p11.2
Pathway : Cell adhesion molecules (CAMs); Hematopoietic cell lineage; Leukocyte transendothelial migration; Regulation of actin cytoskeleton
Function : calcium ion binding; glycoprotein binding; heparan sulfate proteoglycan binding; heparin binding; magnesium ion binding; opsonin binding; protein heterodimerization activity; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does ITGAM contribute to the adhesion and migration of leukocytes? 02/11/2022

It facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.

What potential therapeutic applications arise from targeting ITGAM in immune-related disorders? 04/14/2020

Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.

How do genetic variations in ITGAM affect immune responses and susceptibility to autoimmune diseases? 03/01/2020

Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.

What role does ITGAM play in the immune system's response to infection? 11/02/2019

ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.

How does ITGAM interact with other components of the immune system? 12/21/2018

ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.

What is the primary role of ITGAM in immune cell function? 04/08/2018

ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.

What is the impact of altered ITGAM activity on inflammatory processes? 04/04/2017

Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.

Customer Reviews (3)

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Reviews
12/10/2022

    Reliable data for credibility. Trusted for results.

    02/27/2022

      Timely and precise results. Accelerates our research timelines.

      06/27/2018

        Efficient and dependable service. Enhances research quality.

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