Recombinant Human Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit)
Cat.No. : | ITGAM-4257H |
Product Overview : | CD11b Human Recombinant (aa 936-1154) expressed in E.coli, shows a 52 kDa band on SDS-PAGE. The CD11b is purified by proprietary chromatographic techniques. |
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- Gene Information
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Cat. No. : | ITGAM-4257H |
Description : | Leukocyte associated protein consists of two polypeptide chains with molecular weights 95 and 170kDa. The moleculae functions as a cell surface receptor for the C3bi complement fragment. It belongs to family of heterodimeric proteins (designated CD11) which share a common beta chain CD18 of 95kDa. The alpha chain component of the leukocyte associated antigen is expressed on granulocytes, monocytes and macrophages. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | CD11b in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. |
Physical Appearance : | Sterile Filtered clear solution. |
Storage : | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles. |
Gene Name : | ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) [ Homo sapiens ] |
Official Symbol : | ITGAM |
Synonyms : | ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit); CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; MGC117044; integrin alpha M; antigen CD11b (p170); macrophage antigen alpha polypeptide; neutrophil adherence receptor alpha-M subunit; CD11b; CD11 antigen-like family member B; CD11b antigen; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; integrin, alpha M (complement component 3 receptor 3 subunit); integrin, alpha M (complement component receptor 3, alpha; CD11b (p170), macrophage antigen alpha polypeptide); Integrin alpha-M |
Gene ID : | 3684 |
mRNA Refseq : | NM_000632 |
Protein Refseq : | NP_000623 |
MIM : | 120980 |
UniProt ID : | P11215 |
Chromosome Location : | 16p11.2 |
Pathway : | Cell adhesion molecules (CAMs); Hematopoietic cell lineage; Leukocyte transendothelial migration; Regulation of actin cytoskeleton |
Function : | calcium ion binding; glycoprotein binding; heparan sulfate proteoglycan binding; heparin binding; magnesium ion binding; opsonin binding; protein heterodimerization activity; receptor activity |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.
Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.
Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.
ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.
ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.
ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.
Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.
Customer Reviews (3)
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Timely and precise results. Accelerates our research timelines.
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