|Description:||This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. This protein transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain, into hydrogen peroxide and diatomic oxygen. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.|
|Research topic:||Energy metabolism and body weight regulation|
|Storage:||Superoxide dismutase 2 is supplied with a vial of storage buffer (20 mM Tris, pH7.5). Store at -80°C.|
|Gene Name:||SOD2 superoxide dismutase 2, mitochondrial [ Homo sapiens ]|
|Synonyms:||SOD2; superoxide dismutase 2, mitochondrial; IPOB; MNSOD; MVCD6; superoxide dismutase [Mn], mitochondrial; OTTHUMP00000017530; OTTHUMP00000017531; OTTHUMP00000238884; OTTHUMP00000238886; OTTHUMP00000238887; indophenoloxidase B; Mn superoxide dismutase; mangano-superoxide dismutase; manganese-containing superoxide dismutase|
|Pathway:||FoxO family signaling; Huntington"s disease; Oxidative Stress; Peroxisome; Selenium Pathway|
|Function:||DNA binding; identical protein binding; manganese ion binding; manganese ion binding; oxidoreductase activity; oxygen binding; protein binding; superoxide dismutase activity|
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