"IL17A" Related Products


Recombinant Human IL17A

Cat. No.: IL17A-333H
Product Overview: Human IL17A (Q16552, 20 a.a.-134 a.a.) partial recombinant protein expressed in Escherichia coli.
Description: Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Theoretical MW (kDa): 16
Form: Lyophilized
Preparation Method: Escherichia coli expression system
Purity: > 95% by SDS-PAGE and HPLC
Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
Activity: The ED50 was determined by the dose-dependent proliferation of induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/mL., corresponding to a specific activity of < 5 x 105 units/mg.
Application: SDS-PAGE
Storage Buffer: Lyophilized from PBS, pH 7.5
Storage: Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
Unitprot ID: Q16552
Pathways: Cytokine-cytokine receptor interaction
Gene Name: 17A interleukin 17A [ Homo sapiens ]
Official Symbol: IL12B
Synonyms: IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; toxic T-lymphocyte-associated antigen 8; otoxic T-lymphocyte-associated protein 8; cytotoxic T-lymphocyte-associated serine esterase 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Gene ID: 3605
mRNA Refseq: NM_002190
Protein Refseq: NP_002181
MIM: 603149
Chromosome Location: 6p12
Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

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