"IL18" Related Products

Expand
Expand
Expand

Recombinant Human IL18 (37-193aa)

Cat. No.: IL18-335H
Product Overview: Human IL18 (Q14116, 37 a.a.-193 a.a.) partial recombinant protein expressed in Escherichia coli.
Description: Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-μ (IFN-μ) or type II interferon that plays an important role in activating the macrophages or other cells.
Sequence: ENLESDYFGK LESKLSVIRN LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED
Theoretical MW (kDa): 18
Form: Liquid
Preparation Method: Escherichia coli expression system
Purity: > 98% by SDS-PAGE and HPLC
Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
Activity: The ED50 was determined by the dose-dependent proliferation of human PBMC co-stimulated with IL-12 cells was found to be in the range of 5 ng/mL
Application: SDS-PAGE
Storage Buffer: In PBS
Storage: Store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
Unitprot ID: P01563
Pathways: African trypanosomiasis; African trypanosomiasis; Cellular roles of Anthrax toxin; Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Cytosolic DNA-sensing pathway; Hypertrophy Model; IL12 signaling mediated by STAT4; IL12-mediated signaling events; IL23-mediated signaling events; Influenza A; Interleukin-1 processing; Malaria; NOD-like receptor signaling pathway; Rheumatoid arthritis; Signaling by Interleukins; Signaling in Immune system; Tuberculosis
Gene Name: IL18 interleukin 18 (interferon-gamma-inducing factor) [ Homo sapiens ]
Official Symbol: IL18
Synonyms: IL18; interleukin 18 (interferon-gamma-inducing factor); IGIF; IL-18; IL-1g; IL1F4; MGC12320; interleukin-18; IL-1 gamma; iboctadekin; OTTHUMP00000234749; OTTHUMP00000234750; OTTHUMP00000234751; interleukin-1 gamma; IFN-gamma-inducing factor; Interferon gamma-inducing factor; Iboctadekin; Interleukin-1 gamma
Gene ID: 3606
mRNA Refseq: NM_001562
Protein Refseq: NP_001553
MIM: 600953
Chromosome Location: Q14116
Function: cytokine activity; cytokine activity; signal transducer activity

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.