| Cat. No. : |
IL18-335H |
| Description : |
Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine. IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-μ (IFN-μ) or type II interferon that plays an important role in activating the macrophages or other cells. |
| Sequence : |
ENLESDYFGK LESKLSVIRN LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED |
| Theoretical MW (kDa) : |
18 |
| Form : |
Liquid |
| Preparation Method : |
Escherichia coli expression system |
| Purity : |
> 98% by SDS-PAGE and HPLC |
| Endotoxin Level : |
< 0.1 ng/ug (1 EU/ug) |
| Activity : |
The ED50 was determined by the dose-dependent proliferation of human PBMC co-stimulated with IL-12 cells was found to be in the range of 5 ng/mL |
| Application : |
SDS-PAGE |
| Storage Buffer : |
In PBS |
| Storage : |
Store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing. |
| Unitprot ID : |
P01563 |
| Pathways : |
African trypanosomiasis; African trypanosomiasis; Cellular roles of Anthrax toxin; Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Cytosolic DNA-sensing pathway; Hypertrophy Model; IL12 signaling mediated by STAT4; IL12-mediated signaling events; IL23-mediated signaling events; Influenza A; Interleukin-1 processing; Malaria; NOD-like receptor signaling pathway; Rheumatoid arthritis; Signaling by Interleukins; Signaling in Immune system; Tuberculosis |
