Active Recombinant Human TGFB1
Cat.No. : | TGFB1-539H |
Product Overview : | Human TGFB1 (P01137) full-elngth recombinant protein expressed in CHO cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TGFB1-539H |
Description : | Transforming growth factor beta 1 or TGF-μ1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-μ1 is encoded by the TGFB1 gene. |
Theoretical MW (kDa) : | 25 |
Form : | Lyophilized |
Preparation Method : | Mammalian cell (CHO) expression system |
Purity : | μ 98% by SDS-PAGE, μ 98% by HPLC |
Endotoxin Level : | < 0.1 ng/ug |
Activity : | The ED50 as determined by the ability of TGF-beta1 to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is < 0.05 ng/mL, corresponding to a specific activity of > 2 x 107 units/mg. |
Application : | SDS-PAGE |
Storage Buffer : | Lyophilized from sodium citrate, pH 3.5 |
Storage : | Store at -20°C on dry atmosphere. |
Unitprot ID : | P01137 |
Gene Name : | TGFB1 transforming growth factor, beta 1 [ Homo sapiens ] |
Official Symbol : | TGFB1 |
Synonyms : | TGFB1; transforming growth factor, beta 1; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; Camurati-Engelmann disease; Transforming growth factor beta-1; TGF-beta-1; Latency-associated peptide; LAP |
Gene ID : | 7040 |
mRNA Refseq : | NM_000660 |
Protein Refseq : | NP_000651 |
MIM : | 190180 |
Chromosome Location : | 19q13.1 |
Pathway : | Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway; Hemostasis; Influenza Infection; Signaling by TGF beta |
Function : | growth factor activity; protein N-terminus binding; protein heterodimerization activity; protein homodimerization activity; transcription activator activity; type II transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding |
Products Types
◆ Recombinant Protein | ||
TGFB1-37H | Recombinant Human/Bovine/Porcine TGFB1 Protein | +Inquiry |
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TGFB1-286H | Active Recombinant Human TGFB1 Protein (Ala279-Ser390), C-His tagged, Animal-free, Carrier-free | +Inquiry |
TGFB1-46H | Active Recombinant Human TGFB1 Protein, Animal Free | +Inquiry |
TGFB1-301P | Recombinant Active Pig TGFB1 Protein, His-tagged(C-ter) | +Inquiry |
◆ Native Protein | ||
TGFB1-21H | Active Native Human TGF- β1 | +Inquiry |
◆ Lysates | ||
TGFB1-001MCL | Recombinant Mouse TGFB1 cell lysate | +Inquiry |
TGFB1-001HCL | Recombinant Human TGFB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTGFB1 stimulates the activity of cells involved in bone formation (osteoblasts) and plays a role in regulating bone resorption by influencing osteoclast function.
Potential side effects of anti-TGFB1 therapies may include immune system suppression, gastrointestinal issues, and skin reactions.
TGFB1 levels have been studied as potential biomarkers for diseases like cancer and fibrosis, aiding in diagnosis and monitoring disease progression.
TGFB1 plays a critical role in wound healing by stimulating the formation of new blood vessels, promoting the production of extracellular matrix, and aiding in the migration of cells to the wound site.
TGFB1 can induce the production of excessive extracellular matrix proteins, leading to tissue scarring and fibrosis in organs such as the liver, lung, and kidneys.
Customer Reviews (3)
Write a reviewThe impressive performance of the TGFB1 protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.
Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.
The TGFB1 protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.
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