Recombinant Human TGFB1 protein, His-tagged, Biotinylated TGFB1-362H

Recombinant Human TGFB1 protein, His-tagged, Biotinylated


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Recombinant Human TGFB1 protein, His-tagged, Biotinylated

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Cat.No. : TGFB1-362H
Product Overview : Biotinylated recombinant Human TGFB1 protein (Met1-Ser390) was fused to His-tag at the C-terminus and expressed in HEK293 cells.
Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Leu30 & Ala279
Form : Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human latent TGFβ1 consists of 370 amino acids and predicts a molecular mass of 42.4 kDa.
Protein length : 370
Endotoxin : <1.0 EU per μg of the protein as determined by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -20 centigrade to -80 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
SDS-PAGE of TGFB1-362H :

Gene Name : TGFB1
Official Symbol : TGFB1
Synonyms : CED; LAP; DPD1; TGFB; IBDIMDE; TGFbeta; TGF-beta1
Gene ID : 7040
mRNA Refseq : NM_000660.7
Protein Refseq : NP_000651.3
MIM : 190180
UniProt ID : P01137

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